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- W4378804880 endingPage "58" @default.
- W4378804880 startingPage "39" @default.
- W4378804880 abstract "There has been extensive exploration of how cells may serve as advanced therapy medicinal products to treat skeletal pathologies. Osteoblast progenitors responsible for production of extracellular matrix that is subsequently mineralized during bone formation have been characterised as a rare bone marrow subpopulation of cell culture plastic adherent cells. Conveniently, they proliferate to form single-cell derived colonies of fibroblastoid cells, termed colony forming unit fibroblasts that can subsequently differentiate to aggregates resembling small areas of cartilage or bone. However, donor heterogeneity and loss of osteogenic differentiation capacity during extended cell culture have made the discovery of reliable potency assay biomarkers difficult. Nonetheless, functional osteoblast models derived from telomerised human bone marrow stromal cells have allowed extensive comparative analysis of gene expression, microRNA, morphological phenotypes and secreted proteins. This chapter highlights numerous insights into the molecular mechanisms underpinning osteogenic differentiation of multipotent stromal cells and bone formation, discussing aspects involved in the choice of useful biomarkers for functional attributes that can be quantitively measured in osteogenic potency assays." @default.
- W4378804880 created "2023-06-01" @default.
- W4378804880 creator A5001649340 @default.
- W4378804880 creator A5035262769 @default.
- W4378804880 date "2023-01-01" @default.
- W4378804880 modified "2023-10-17" @default.
- W4378804880 title "Identifying Biomarkers for Osteogenic Potency Assay Development" @default.
- W4378804880 cites W1514803062 @default.
- W4378804880 cites W1523740484 @default.
- W4378804880 cites W1544527238 @default.
- W4378804880 cites W1566246481 @default.
- W4378804880 cites W1624294703 @default.
- W4378804880 cites W1630483749 @default.
- W4378804880 cites W1708123803 @default.
- W4378804880 cites W1820629163 @default.
- W4378804880 cites W1890394592 @default.
- W4378804880 cites W1918057567 @default.
- W4378804880 cites W1959519492 @default.
- W4378804880 cites W1961169397 @default.
- W4378804880 cites W1965437277 @default.
- W4378804880 cites W1965924854 @default.
- W4378804880 cites W1969613473 @default.
- W4378804880 cites W1970278573 @default.
- W4378804880 cites W1972222251 @default.
- W4378804880 cites W1972228155 @default.
- W4378804880 cites W1979155684 @default.
- W4378804880 cites W1982323513 @default.
- W4378804880 cites W1982579673 @default.
- W4378804880 cites W1983460320 @default.
- W4378804880 cites W1983582703 @default.
- W4378804880 cites W1985044565 @default.
- W4378804880 cites W1990666022 @default.
- W4378804880 cites W1993737058 @default.
- W4378804880 cites W1995286352 @default.
- W4378804880 cites W1997675408 @default.
- W4378804880 cites W1998650056 @default.
- W4378804880 cites W2002856735 @default.
- W4378804880 cites W2003079057 @default.
- W4378804880 cites W2004247546 @default.
- W4378804880 cites W2005720110 @default.
- W4378804880 cites W2005865470 @default.
- W4378804880 cites W2010622545 @default.
- W4378804880 cites W2011664904 @default.
- W4378804880 cites W2016126437 @default.
- W4378804880 cites W2016547417 @default.
- W4378804880 cites W2017271806 @default.
- W4378804880 cites W2019196925 @default.
- W4378804880 cites W2022346732 @default.
- W4378804880 cites W2025282925 @default.
- W4378804880 cites W2025371271 @default.
- W4378804880 cites W2027284829 @default.
- W4378804880 cites W2033514910 @default.
- W4378804880 cites W2033975133 @default.
- W4378804880 cites W2035176325 @default.
- W4378804880 cites W2035379099 @default.
- W4378804880 cites W2037536118 @default.
- W4378804880 cites W2044769151 @default.
- W4378804880 cites W2045301131 @default.
- W4378804880 cites W2047470479 @default.
- W4378804880 cites W2051441559 @default.
- W4378804880 cites W2052801322 @default.
- W4378804880 cites W2055464482 @default.
- W4378804880 cites W2061570844 @default.
- W4378804880 cites W2070013317 @default.
- W4378804880 cites W2070027660 @default.
- W4378804880 cites W2070640771 @default.
- W4378804880 cites W2074526547 @default.
- W4378804880 cites W2078489918 @default.
- W4378804880 cites W2081134904 @default.
- W4378804880 cites W2081592256 @default.
- W4378804880 cites W2084914185 @default.
- W4378804880 cites W2086819446 @default.
- W4378804880 cites W2089129295 @default.
- W4378804880 cites W2091464648 @default.
- W4378804880 cites W2092716023 @default.
- W4378804880 cites W2098115598 @default.
- W4378804880 cites W2106096051 @default.
- W4378804880 cites W2111112139 @default.
- W4378804880 cites W2111177772 @default.
- W4378804880 cites W2113358240 @default.
- W4378804880 cites W2115996219 @default.
- W4378804880 cites W2116104054 @default.
- W4378804880 cites W2118939519 @default.
- W4378804880 cites W2123429544 @default.
- W4378804880 cites W2126868456 @default.
- W4378804880 cites W2130273189 @default.
- W4378804880 cites W2136853488 @default.
- W4378804880 cites W2144268541 @default.
- W4378804880 cites W2144630934 @default.
- W4378804880 cites W2146710021 @default.
- W4378804880 cites W2157363121 @default.
- W4378804880 cites W2163978342 @default.
- W4378804880 cites W2172503413 @default.
- W4378804880 cites W2177496056 @default.
- W4378804880 cites W2235056514 @default.
- W4378804880 cites W2269475172 @default.
- W4378804880 cites W2284692617 @default.
- W4378804880 cites W2317764313 @default.