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- W4378806684 abstract "Background The proximal region of the mouse epididymis plays a pivotal role in sperm transport, sperm maturation, and male fertility. Several studies have focused on segment-dependent gene expression of the mouse epididymis through high-throughput sequencing without the precision of the microdissection. Methods and results Herein, we isolated the initial segment (IS) and proximal caput (P-caput) by physical microdissection using an Lcn9 - cre ; Rosa26 tdTomato mouse model. We defined the transcriptome changes of caput epididymis by RNA sequencing (RNA-seq), which identified 1,961 genes that were abundantly expressed in the IS and 1,739 genes that were prominently expressed in the P-caput. In addition, we found that many differentially expressed genes (DEGs) were predominantly or uniquely expressed in the epididymis and region-specific genes were highly associated with transport, secretion, sperm motility, fertilization, and male fertility. Conclusion Thus, this study provides an RNA-seq resource to identify region-specific genes in the caput epididymis. The epididymal-selective/specific genes are potential targets for male contraception and may provide new insights into understanding segment-specific epididymal microenvironment-mediated sperm transport, maturation, and male fertility." @default.
- W4378806684 created "2023-06-01" @default.
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- W4378806684 date "2023-05-31" @default.
- W4378806684 modified "2023-09-27" @default.
- W4378806684 title "Transcriptome profiling of the initial segment and proximal caput of mouse epididymis" @default.
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- W4378806684 doi "https://doi.org/10.3389/fendo.2023.1190890" @default.
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