Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378839776> ?p ?o ?g. }
- W4378839776 endingPage "124932" @default.
- W4378839776 startingPage "124932" @default.
- W4378839776 abstract "WTAP, a highly conserved Wilms' tumor 1 interacting protein, is involved in a variety of biological processes. However, functional studies of WTAP in planarians have not been reported. In this study, we examined the spatiotemporal expression pattern of planarian DjWTAP and investigated its functions in planarians regeneration and homeostasis. Knocking-down DjWTAP resulted in severe morphological defects leading to lethality within 20 days. Silencing DjWTAP promoted the proliferation of PiwiA+ cells but impaired the lineage differentiation of epidermal, neural, digestive, and excretory cell types, suggesting a critical role for DjWTAP in stem cell self-renewal and differentiation in planarian. To further investigate the mechanisms underlying the defective differentiation, RNA-seq was employed to determine the transcriptomic alterations upon DjWTAP RNA interference. Histone 4 (H4), Histone-lysine N-methyltransferase-SETMAR like, and TNF receptor-associated factor 6 (TRAF6), were significantly upregulated in response to DjWTAP RNAi. Knocking-down TRAF6 largely rescued the defective tissue homeostasis and regeneration resulted from DjWTAP knockdown in planarians, suggesting that DjWTAP maintains planarian regeneration and homeostasis via TRAF6." @default.
- W4378839776 created "2023-06-01" @default.
- W4378839776 creator A5004629089 @default.
- W4378839776 creator A5005123718 @default.
- W4378839776 creator A5027964355 @default.
- W4378839776 creator A5032940656 @default.
- W4378839776 creator A5038666893 @default.
- W4378839776 creator A5077078418 @default.
- W4378839776 creator A5087055335 @default.
- W4378839776 creator A5090425882 @default.
- W4378839776 date "2023-07-01" @default.
- W4378839776 modified "2023-10-15" @default.
- W4378839776 title "WTAP regulates stem cells via TRAF6 to maintain planarian homeostasis and regeneration" @default.
- W4378839776 cites W1709431973 @default.
- W4378839776 cites W1902811474 @default.
- W4378839776 cites W1977830503 @default.
- W4378839776 cites W1986260964 @default.
- W4378839776 cites W1988407787 @default.
- W4378839776 cites W1995117011 @default.
- W4378839776 cites W1999574084 @default.
- W4378839776 cites W2027847170 @default.
- W4378839776 cites W2037754272 @default.
- W4378839776 cites W2042898339 @default.
- W4378839776 cites W2045097086 @default.
- W4378839776 cites W2048109276 @default.
- W4378839776 cites W2058735593 @default.
- W4378839776 cites W2079683330 @default.
- W4378839776 cites W2089842581 @default.
- W4378839776 cites W2091235283 @default.
- W4378839776 cites W2091966685 @default.
- W4378839776 cites W2099919984 @default.
- W4378839776 cites W2102585554 @default.
- W4378839776 cites W2105101298 @default.
- W4378839776 cites W2137033662 @default.
- W4378839776 cites W2138606042 @default.
- W4378839776 cites W2143595402 @default.
- W4378839776 cites W2144375779 @default.
- W4378839776 cites W2150712568 @default.
- W4378839776 cites W2154250428 @default.
- W4378839776 cites W2155763709 @default.
- W4378839776 cites W2160546595 @default.
- W4378839776 cites W2161671321 @default.
- W4378839776 cites W2179438025 @default.
- W4378839776 cites W2184563250 @default.
- W4378839776 cites W2558981096 @default.
- W4378839776 cites W2791366345 @default.
- W4378839776 cites W2794159961 @default.
- W4378839776 cites W2808909535 @default.
- W4378839776 cites W2809029366 @default.
- W4378839776 cites W2889007771 @default.
- W4378839776 cites W2891260560 @default.
- W4378839776 cites W2893758775 @default.
- W4378839776 cites W2895635508 @default.
- W4378839776 cites W2913141021 @default.
- W4378839776 cites W2947013137 @default.
- W4378839776 cites W2949594511 @default.
- W4378839776 cites W3002028658 @default.
- W4378839776 cites W3092085676 @default.
- W4378839776 cites W3094104800 @default.
- W4378839776 cites W3112689518 @default.
- W4378839776 cites W3132838177 @default.
- W4378839776 cites W3137888698 @default.
- W4378839776 cites W3153804619 @default.
- W4378839776 cites W3190249998 @default.
- W4378839776 cites W3194282181 @default.
- W4378839776 cites W3205464070 @default.
- W4378839776 cites W329953562 @default.
- W4378839776 cites W41125336 @default.
- W4378839776 cites W4207003019 @default.
- W4378839776 cites W4221136653 @default.
- W4378839776 cites W4224222968 @default.
- W4378839776 cites W4285808788 @default.
- W4378839776 doi "https://doi.org/10.1016/j.ijbiomac.2023.124932" @default.
- W4378839776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37268082" @default.
- W4378839776 hasPublicationYear "2023" @default.
- W4378839776 type Work @default.
- W4378839776 citedByCount "1" @default.
- W4378839776 countsByYear W43788397762023 @default.
- W4378839776 crossrefType "journal-article" @default.
- W4378839776 hasAuthorship W4378839776A5004629089 @default.
- W4378839776 hasAuthorship W4378839776A5005123718 @default.
- W4378839776 hasAuthorship W4378839776A5027964355 @default.
- W4378839776 hasAuthorship W4378839776A5032940656 @default.
- W4378839776 hasAuthorship W4378839776A5038666893 @default.
- W4378839776 hasAuthorship W4378839776A5077078418 @default.
- W4378839776 hasAuthorship W4378839776A5087055335 @default.
- W4378839776 hasAuthorship W4378839776A5090425882 @default.
- W4378839776 hasConcept C104317684 @default.
- W4378839776 hasConcept C119056186 @default.
- W4378839776 hasConcept C127561419 @default.
- W4378839776 hasConcept C148738053 @default.
- W4378839776 hasConcept C166703698 @default.
- W4378839776 hasConcept C171056886 @default.
- W4378839776 hasConcept C173396325 @default.
- W4378839776 hasConcept C2775935104 @default.
- W4378839776 hasConcept C28328180 @default.
- W4378839776 hasConcept C54355233 @default.
- W4378839776 hasConcept C67705224 @default.