Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378840260> ?p ?o ?g. }
- W4378840260 endingPage "2641" @default.
- W4378840260 startingPage "2623" @default.
- W4378840260 abstract "Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D), which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy (DPN), the most common microvascular complication, is length-dependent damage to peripheral nerves. DPN pathogenesis is complex, but, at its core, it can be viewed as a state of impaired metabolism and bioenergetics failure operating against the backdrop of long peripheral nerve axons supported by glia. This unique peripheral nerve anatomy and the injury consequent to T2D underpins the distal-to-proximal symptomatology of DPN. Earlier work focused on the impact of hyperglycemia on nerve damage and bioenergetics failure, but recent evidence additionally implicates contributions from obesity and dyslipidemia. This review will cover peripheral nerve anatomy, bioenergetics, and glia-axon interactions, building the framework for understanding how hyperglycemia and dyslipidemia induce bioenergetics failure in DPN. DPN and painful DPN still lack disease-modifying therapies, and research on novel mechanism-based approaches is also covered." @default.
- W4378840260 created "2023-06-01" @default.
- W4378840260 creator A5009683197 @default.
- W4378840260 creator A5010154720 @default.
- W4378840260 creator A5012864068 @default.
- W4378840260 creator A5038399373 @default.
- W4378840260 creator A5056304003 @default.
- W4378840260 creator A5068376728 @default.
- W4378840260 creator A5091883761 @default.
- W4378840260 date "2023-09-01" @default.
- W4378840260 modified "2023-10-17" @default.
- W4378840260 title "New perspectives in diabetic neuropathy" @default.
- W4378840260 cites W1831581079 @default.
- W4378840260 cites W1938236935 @default.
- W4378840260 cites W1963837394 @default.
- W4378840260 cites W1967540887 @default.
- W4378840260 cites W1971183383 @default.
- W4378840260 cites W1972940420 @default.
- W4378840260 cites W1988527155 @default.
- W4378840260 cites W1999090141 @default.
- W4378840260 cites W2003086985 @default.
- W4378840260 cites W2003945891 @default.
- W4378840260 cites W2010869886 @default.
- W4378840260 cites W2018121762 @default.
- W4378840260 cites W2018707257 @default.
- W4378840260 cites W2024720175 @default.
- W4378840260 cites W2026983868 @default.
- W4378840260 cites W2027000884 @default.
- W4378840260 cites W2030691946 @default.
- W4378840260 cites W2038811384 @default.
- W4378840260 cites W2043054174 @default.
- W4378840260 cites W2043406394 @default.
- W4378840260 cites W2048360724 @default.
- W4378840260 cites W2055476783 @default.
- W4378840260 cites W2057578432 @default.
- W4378840260 cites W2061237420 @default.
- W4378840260 cites W2061605734 @default.
- W4378840260 cites W2069297513 @default.
- W4378840260 cites W2072140823 @default.
- W4378840260 cites W2079761925 @default.
- W4378840260 cites W2082027305 @default.
- W4378840260 cites W2082326637 @default.
- W4378840260 cites W2083264147 @default.
- W4378840260 cites W2085029391 @default.
- W4378840260 cites W2086612059 @default.
- W4378840260 cites W2090789207 @default.
- W4378840260 cites W2092211307 @default.
- W4378840260 cites W2093167786 @default.
- W4378840260 cites W2097289714 @default.
- W4378840260 cites W2104818454 @default.
- W4378840260 cites W2105042598 @default.
- W4378840260 cites W2105731956 @default.
- W4378840260 cites W2109661060 @default.
- W4378840260 cites W2112180189 @default.
- W4378840260 cites W2113880168 @default.
- W4378840260 cites W2118860915 @default.
- W4378840260 cites W2119590183 @default.
- W4378840260 cites W2119878763 @default.
- W4378840260 cites W2128865950 @default.
- W4378840260 cites W2143787024 @default.
- W4378840260 cites W2144798177 @default.
- W4378840260 cites W2146537980 @default.
- W4378840260 cites W2151657502 @default.
- W4378840260 cites W2152676966 @default.
- W4378840260 cites W2155399617 @default.
- W4378840260 cites W2155483535 @default.
- W4378840260 cites W2160535648 @default.
- W4378840260 cites W2162902338 @default.
- W4378840260 cites W2165230539 @default.
- W4378840260 cites W2168868325 @default.
- W4378840260 cites W2169156123 @default.
- W4378840260 cites W2171657190 @default.
- W4378840260 cites W2281365535 @default.
- W4378840260 cites W2306460448 @default.
- W4378840260 cites W2316569153 @default.
- W4378840260 cites W2323275321 @default.
- W4378840260 cites W2404807319 @default.
- W4378840260 cites W2419165202 @default.
- W4378840260 cites W2437843547 @default.
- W4378840260 cites W2522080051 @default.
- W4378840260 cites W2561727131 @default.
- W4378840260 cites W2562461810 @default.
- W4378840260 cites W2597734448 @default.
- W4378840260 cites W2598267597 @default.
- W4378840260 cites W2605239780 @default.
- W4378840260 cites W2606188258 @default.
- W4378840260 cites W2613942025 @default.
- W4378840260 cites W2616599606 @default.
- W4378840260 cites W2726668995 @default.
- W4378840260 cites W2755523064 @default.
- W4378840260 cites W2757842300 @default.
- W4378840260 cites W2769408126 @default.
- W4378840260 cites W2772219889 @default.
- W4378840260 cites W2782647253 @default.
- W4378840260 cites W2789633053 @default.
- W4378840260 cites W2790769408 @default.
- W4378840260 cites W2791493912 @default.
- W4378840260 cites W2791555038 @default.