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- W4378840687 abstract "The treatment of a variety of recurrent or resistant hematologic malignancies with chimeric antigen receptor T cell (CAR- T) cell therapy has seen significant success in recent years. The current CAR- T cell therapy approach is not without flaws, nevertheless, and there are still several issues with clinical treatment, including antigen escape, significant toxicity, and sus-ceptibility to drug-resistant recurrence. This paper introduces the structural development and characteristics of CAR-T cells, reviews the limitations of CAR- T cell therapy, including an-tigen escape, toxicity, CAR-T cell depletion and drug-resistant relapse after treatment, and summarizes the related improvement and optimization strategies. The paper concludes that CAR-T cell immunotherapy has brought new hope to patients with hematologic malignancies, making a cure for refractory and recurrent hematologic malignancies possible. Although CAR-T cell therapy still has many challenges at present, such as immunogenicity, drug re-sistance, and toxicity." @default.
- W4378840687 created "2023-06-01" @default.
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- W4378840687 date "2023-04-28" @default.
- W4378840687 modified "2023-10-07" @default.
- W4378840687 title "Editing Mutations of GABRB3 Using CRISPR-Cas9 as a Potential Treatment for Epilepsy and Autism Spectrum Disorders" @default.
- W4378840687 doi "https://doi.org/10.54254/2753-8818/3/20220273" @default.
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