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- W4378875462 abstract "Bone grafts are used in orthopaedics for treatment of conditions including tumours, trauma, and infection, and critical-sized defects that do not spontaneously heal without surgical intervention. While autografts harvested from the patient’s body and allografts from donors are often used as graft material, a wide variety of synthetic bone graft substitutes are also available as alternatives. In this study, we aimed to determine how calcium phosphate/collagen ratio would influence the capacity of a biphasic bone graft to support bone repair. The in vitro degradation of scaffolds with three different calcium phosphate/collagen ratios were evaluated in PBS over 7 days. It was found that higher calcium phosphate/collagen ratios resulted in less pH decrease, and scaffolds with a lower calcium phosphate/collagen ratio plateaued at higher pH. The in vivo performance of the three implants were evaluated in a femoral condyle defect model in New Zealand White Rabbits over 12 weeks, and the results obtained revealed that calcium phosphate/collagen ratios have no significant impact on degradation rates of the calcium phosphate component of the biphasic scaffold. Percentage of bone growth, on the other hand, increased from 15.4 to 25.8% from the lowest to highest calcium phosphate/collagen ratios, potentially due to calcium phosphate’s osteoconductive properties. Overall, higher proportions of calcium phosphate to collagen led to better outcomes in defect healing due to greater bone formation, and matching implant resorption and bone growth rates." @default.
- W4378875462 created "2023-06-01" @default.
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- W4378875462 date "2023-01-01" @default.
- W4378875462 modified "2023-09-30" @default.
- W4378875462 title "Calcium Phosphate/Collagen Ratio in Bone Grafts Influences Bone Repair in a Rabbit Femoral Condyle Defect Model" @default.
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- W4378875462 doi "https://doi.org/10.1007/978-981-19-7222-5_36" @default.
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