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• W4378882528 endingPage "4452" @default.
• W4378882528 startingPage "4452" @default.
• W4378882528 abstract "The vulnerabilities of cancer cells constitute a promising strategy for drug therapeutics. This paper integrates proteomics, bioinformatics, and cell genotype together with in vitro cell proliferation assays to identify key biological processes and potential novel kinases that could account, at least in part, for the clinical differences observed in colorectal cancer (CRC) patients. This study started by focusing on CRC cell lines stratified by their microsatellite (MS) state and p53 genotype. It shows that cell-cycle checkpoint, metabolism of proteins and RNA, signal transduction, and WNT signaling processes are significantly more active in MSI-High p53-WT cell lines. Conversely, MSI-High cell lines with a mutant (Mut) p53 gene showed hyperactivation of cell signaling, DNA repair, and immune-system processes. Several kinases were linked to these phenotypes, from which RIOK1 was selected for additional exploration. We also included the KRAS genotype in our analysis. Our results showed that RIOK1's inhibition in CRC MSI-High cell lines was dependent on both the p53 and KRAS genotypes. Explicitly, Nintedanib showed relatively low cytotoxicity in MSI-High with both mutant p53 and KRAS (HCT-15) but no inhibition in p53 and KRAS WT (SW48) MSI-High cells. This trend was flipped in CRC MSI-High bearing opposite p53-KRAS genotypes (e.g., p53-Mut KRAS-WT or p53-WT KRAS-Mut), where observed cytotoxicity was more extensive compared to the p53-KRAS WT-WT or Mut-Mut cells, with HCT 116 (KRAS-Mut and p53-WT) being the most sensitive to RIOK1 inhibition. These results highlight the potential of our in silico computational approach to identify novel kinases in CRC sub-MSI-High populations as well as the importance of clinical genomics in determining drug potency." @default.
• W4378882528 created "2023-06-01" @default.
• W4378882528 creator A5013530081 @default.
• W4378882528 creator A5019778451 @default.
• W4378882528 creator A5023681686 @default.
• W4378882528 creator A5031716809 @default.
• W4378882528 creator A5071351984 @default.
• W4378882528 date "2023-05-31" @default.
• W4378882528 modified "2023-09-26" @default.
• W4378882528 title "Riok1, A Novel Potential Target in MSI-High p53 Mutant Colorectal Cancer Cells" @default.
• W4378882528 cites W1500913284 @default.
• W4378882528 cites W156511211 @default.
• W4378882528 cites W1968075505 @default.
• W4378882528 cites W1977925553 @default.
• W4378882528 cites W1984642649 @default.
• W4378882528 cites W1989277387 @default.
• W4378882528 cites W1995068068 @default.
• W4378882528 cites W1995819860 @default.
• W4378882528 cites W2004451132 @default.
• W4378882528 cites W2005834057 @default.
• W4378882528 cites W2009931781 @default.
• W4378882528 cites W2013011994 @default.
• W4378882528 cites W2015619266 @default.
• W4378882528 cites W2018348035 @default.
• W4378882528 cites W2027032515 @default.
• W4378882528 cites W2032379069 @default.
• W4378882528 cites W2032440908 @default.
• W4378882528 cites W2032461554 @default.
• W4378882528 cites W2039082276 @default.
• W4378882528 cites W2042020327 @default.
• W4378882528 cites W2042797183 @default.
• W4378882528 cites W2044553306 @default.
• W4378882528 cites W2044643325 @default.
• W4378882528 cites W2050658928 @default.
• W4378882528 cites W2051257252 @default.
• W4378882528 cites W2068492235 @default.
• W4378882528 cites W2070180064 @default.
• W4378882528 cites W2071841826 @default.
• W4378882528 cites W2085653208 @default.
• W4378882528 cites W2088010622 @default.
• W4378882528 cites W2092513068 @default.
• W4378882528 cites W2094390470 @default.
• W4378882528 cites W2096766502 @default.
• W4378882528 cites W2130410032 @default.
• W4378882528 cites W2137989314 @default.
• W4378882528 cites W2159482845 @default.
• W4378882528 cites W2160595349 @default.
• W4378882528 cites W2167143405 @default.
• W4378882528 cites W2168680994 @default.
• W4378882528 cites W2262414037 @default.
• W4378882528 cites W2272741207 @default.
• W4378882528 cites W2321587450 @default.
• W4378882528 cites W2441866534 @default.
• W4378882528 cites W2462053388 @default.
• W4378882528 cites W2546257383 @default.
• W4378882528 cites W2587008251 @default.
• W4378882528 cites W2603328400 @default.
• W4378882528 cites W2605682092 @default.
• W4378882528 cites W2605783169 @default.
• W4378882528 cites W2635415917 @default.
• W4378882528 cites W2727134083 @default.
• W4378882528 cites W2770747919 @default.
• W4378882528 cites W2773619385 @default.
• W4378882528 cites W2786122698 @default.
• W4378882528 cites W2809540352 @default.
• W4378882528 cites W2904049988 @default.
• W4378882528 cites W2913665794 @default.
• W4378882528 cites W2950291696 @default.
• W4378882528 cites W2952755768 @default.
• W4378882528 cites W2953390364 @default.
• W4378882528 cites W2969718750 @default.
• W4378882528 cites W2970045605 @default.
• W4378882528 cites W2970164682 @default.
• W4378882528 cites W2972864093 @default.
• W4378882528 cites W2999729767 @default.
• W4378882528 cites W3005521521 @default.
• W4378882528 cites W3009145316 @default.
• W4378882528 cites W3042462904 @default.
• W4378882528 cites W3083903534 @default.
• W4378882528 cites W3093242429 @default.
• W4378882528 cites W3093660856 @default.
• W4378882528 cites W3094321390 @default.
• W4378882528 cites W3094568106 @default.
• W4378882528 cites W3096828292 @default.
• W4378882528 cites W3161189560 @default.
• W4378882528 cites W3195901433 @default.
• W4378882528 cites W3211402536 @default.
• W4378882528 cites W4224880107 @default.
• W4378882528 cites W4238513314 @default.
• W4378882528 cites W4280508531 @default.
• W4378882528 cites W4285393971 @default.
• W4378882528 cites W4294216483 @default.
• W4378882528 cites W4304208568 @default.
• W4378882528 cites W4312002237 @default.
• W4378882528 doi "https://doi.org/10.3390/molecules28114452" @default.
• W4378882528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37298928" @default.
• W4378882528 hasPublicationYear "2023" @default.
• W4378882528 type Work @default.

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