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- W4378901907 abstract "Fumarate hydratase–deficient (FH-deficient) renal cell carcinoma (RCC) represents a particularly aggressive form of kidney cancer. FH-deficient RCC arises in the setting of germline, or solely somatic, mutations in the FH gene, a two-hit tumor suppressor gene. Early detection can be curative, but there are no biomarkers, and in the sporadic setting, establishing a diagnosis of FH-deficient RCC is challenging. In this issue of the JCI, Zheng, Zhu, and co-authors report untargeted plasma metabolomic analyses to identify putative biomarkers. They discovered two plasma metabolites directly linked to fumarate overproduction by tumor cells, succinyl-adenosine and succinic-cysteine, which correlate with tumor burden. The identification of circulating biomarkers of FH-deficient RCC may aid in the diagnosis of FH-deficient RCC and provide a means for longitudinal follow-up." @default.
- W4378901907 created "2023-06-01" @default.
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- W4378901907 date "2023-06-01" @default.
- W4378901907 modified "2023-09-26" @default.
- W4378901907 title "Reporting on FH-deficient renal cell carcinoma using circulating succinylated metabolites" @default.
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- W4378901907 doi "https://doi.org/10.1172/jci170195" @default.
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