Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378902413> ?p ?o ?g. }
- W4378902413 abstract "Cognitive impairment associated with old age or various brain disorders may be very disabling for affected individuals, placing their carers and public health services under considerable stress. The standard-of-care drugs produce only transient improvement of cognitive impairment in older people, so the search for novel, safe and effective therapeutics that would help to reverse or delay cognitive impairment is warranted. Repurposing pharmacological therapies with well-established safety record for additional indications is a promising recent trend in drug development. Vertigoheel (VH-04), a multicomponent drug made of Ambra grisea, Anamirta cocculus L., Conium maculatum, and Petroleum rectificatum, has been successfully used for several decades in the treatment of vertigo. Here, we investigated effects of VH-04 on cognitive performance in standard behavioral tests assessing different types of memory and explored cellular and molecular underpinnings of VH-04's biological activity.In the majority of behavioral experiments, namely in the spontaneous and rewarded alternation tests, passive avoidance test, contextual/cued fear conditioning, and social transmission of food preference, we examined the ability of single and repeated intraperitoneal administrations of VH-04 to improve cognitive parameters of mice and rats disrupted by the application of the muscarinic antagonist scopolamine. In addition, we also assessed how VH-04 affected novel object recognition and influenced performance of aged animals in Morris water maze. Furthermore, we also studied the effects of VH-04 on primary hippocampal neurons in vitro and mRNA expression of synaptophysin in the hippocampus.Administration of VH-04 positively influenced visual recognition memory in the novel object recognition test and alleviated the impairments in spatial working memory and olfactory memory caused by the muscarinic antagonist scopolamine in the spontaneous alternation and social transmission of food preference tests. In addition, VH-04 improved retention of the spatial orientation memory of old rats in the Morris water maze. In contrast, VH-04 did not have significant effects on scopolamine-induced impairments in tests of fear-aggravated memory or rewarded alternation. Experiments in vitro showed that VH-04 stimulated neurite growth and possibly reversed the age-dependent decrease in hippocampal synaptophysin mRNA expression, which implies that VH-04 may preserve synaptic integrity in the aging brain.Our findings allow a cautious conclusion that in addition to its ability to alleviate manifestations of vertigo, VH-04 may be also used as a cognitive enhancer." @default.
- W4378902413 created "2023-06-01" @default.
- W4378902413 creator A5008166228 @default.
- W4378902413 creator A5009944461 @default.
- W4378902413 creator A5018266626 @default.
- W4378902413 creator A5026639308 @default.
- W4378902413 creator A5032072911 @default.
- W4378902413 creator A5049506275 @default.
- W4378902413 creator A5051901342 @default.
- W4378902413 creator A5053618830 @default.
- W4378902413 creator A5056334636 @default.
- W4378902413 creator A5071015125 @default.
- W4378902413 creator A5071761326 @default.
- W4378902413 creator A5078967774 @default.
- W4378902413 creator A5080821885 @default.
- W4378902413 creator A5080999858 @default.
- W4378902413 creator A5085590921 @default.
- W4378902413 creator A5091435687 @default.
- W4378902413 date "2023-05-31" @default.
- W4378902413 modified "2023-09-26" @default.
- W4378902413 title "Vertigoheel promotes rodent cognitive performance in multiple memory tests" @default.
- W4378902413 cites W1526553984 @default.
- W4378902413 cites W1574639668 @default.
- W4378902413 cites W1592483428 @default.
- W4378902413 cites W1818258076 @default.
- W4378902413 cites W1844154398 @default.
- W4378902413 cites W1967061503 @default.
- W4378902413 cites W1982371579 @default.
- W4378902413 cites W1993233257 @default.
- W4378902413 cites W1997497060 @default.
- W4378902413 cites W2000212196 @default.
- W4378902413 cites W2001606285 @default.
- W4378902413 cites W2001620606 @default.
- W4378902413 cites W2006922237 @default.
- W4378902413 cites W2012383826 @default.
- W4378902413 cites W2015398244 @default.
- W4378902413 cites W2016676864 @default.
- W4378902413 cites W2025892534 @default.
- W4378902413 cites W2029153167 @default.
- W4378902413 cites W2036669024 @default.
- W4378902413 cites W2043598524 @default.
- W4378902413 cites W2046208577 @default.
- W4378902413 cites W2058722821 @default.
- W4378902413 cites W2065341809 @default.
- W4378902413 cites W2071898373 @default.
- W4378902413 cites W2076348615 @default.
- W4378902413 cites W2076413462 @default.
- W4378902413 cites W2077273976 @default.
- W4378902413 cites W2083118719 @default.
- W4378902413 cites W2083702570 @default.
- W4378902413 cites W2083991194 @default.
- W4378902413 cites W2095173617 @default.
- W4378902413 cites W2124627119 @default.
- W4378902413 cites W2131095682 @default.
- W4378902413 cites W2151087473 @default.
- W4378902413 cites W2151643397 @default.
- W4378902413 cites W2155158396 @default.
- W4378902413 cites W2161074753 @default.
- W4378902413 cites W2162726007 @default.
- W4378902413 cites W2165967237 @default.
- W4378902413 cites W2169931561 @default.
- W4378902413 cites W2247160930 @default.
- W4378902413 cites W2248618879 @default.
- W4378902413 cites W2284841245 @default.
- W4378902413 cites W2321359875 @default.
- W4378902413 cites W2553024664 @default.
- W4378902413 cites W2587915728 @default.
- W4378902413 cites W2737384370 @default.
- W4378902413 cites W2759872597 @default.
- W4378902413 cites W2777739866 @default.
- W4378902413 cites W2780477102 @default.
- W4378902413 cites W2780732598 @default.
- W4378902413 cites W2785143401 @default.
- W4378902413 cites W2791912546 @default.
- W4378902413 cites W2807404979 @default.
- W4378902413 cites W2905877181 @default.
- W4378902413 cites W2912977831 @default.
- W4378902413 cites W2970754735 @default.
- W4378902413 cites W2981720124 @default.
- W4378902413 cites W2984447110 @default.
- W4378902413 cites W2996937621 @default.
- W4378902413 cites W3002574516 @default.
- W4378902413 cites W3008391208 @default.
- W4378902413 cites W3025809694 @default.
- W4378902413 cites W3032468766 @default.
- W4378902413 cites W3066396828 @default.
- W4378902413 cites W3083953877 @default.
- W4378902413 cites W3097424190 @default.
- W4378902413 cites W3121001522 @default.
- W4378902413 cites W3121341029 @default.
- W4378902413 cites W3168854088 @default.
- W4378902413 cites W3199589638 @default.
- W4378902413 cites W33245730 @default.
- W4378902413 cites W4214911569 @default.
- W4378902413 cites W4221026792 @default.
- W4378902413 cites W4225602642 @default.
- W4378902413 cites W4281628431 @default.
- W4378902413 cites W4284900199 @default.
- W4378902413 cites W4285132881 @default.
- W4378902413 cites W4291144680 @default.