FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378903944> ?p ?o ?g. }

• W4378903944 abstract "Consanguineous marriage is defined as marriage between first or second-degree cousins, with high prevalence in many cultures and societies. Descendants from consanguineous unions have an increased risk for genetic diseases. Additionally, in consanguineous couples, chromosomal disjunction during embryogenesis could also be affected, increasing the risk of chromosomal errors. Nowadays, genomic testing allows to identify new genetic syndromes and variants related to copy-number variations (CNV), including whole chromosome, segmental and micro-segmental errors. This is the first study evaluating chromosomal ploidy status on blastocysts formed from consanguineous couples during IVF/ICSI treatments with Preimplantation Genetic Testing for Aneuploidies (PGT-A), compared to non-consanguineous couples. Although consanguine couples were significantly younger, no differences were observed between groups for fertilisation rate, blastulation rate and euploidy rate, once adjusted by age. Nevertheless, the number of blastocysts biopsied on day 5 was lower for consanguine couples. Segmental errors, and aneuploidies of chromosomes 13 and 14 were the most prominent abnormalities in relation to consanguinity, together with errors in chromosome 16 and sex chromosomes when the female partner was younger than 35. Once euploid blastocysts were considered for subsequent frozen embryo transfer, pregnancy outcomes were similar in both groups. The current findings point toward the fact that in consanguine unions, not only the risk of having a child with genetic disorders is increased, but also the risk of specific chromosomal abnormalities seems to be increased. Premarital counselling and tailored reproductive treatments should be offered to these couples." @default.
• W4378903944 created "2023-06-01" @default.
• W4378903944 creator A5012604646 @default.
• W4378903944 creator A5040903293 @default.
• W4378903944 creator A5047037826 @default.
• W4378903944 creator A5048445694 @default.
• W4378903944 creator A5067128915 @default.
• W4378903944 creator A5072875016 @default.
• W4378903944 creator A5074522090 @default.
• W4378903944 creator A5083631105 @default.
• W4378903944 date "2023-05-31" @default.
• W4378903944 modified "2023-09-27" @default.
• W4378903944 title "Features of chromosomal abnormalities in relation to consanguinity: analysis of 10,556 blastocysts from IVF/ICSI cycles with PGT-A from consanguineous and non-consanguineous couples" @default.
• W4378903944 cites W1486619343 @default.
• W4378903944 cites W1511613411 @default.
• W4378903944 cites W1526264567 @default.
• W4378903944 cites W1863746743 @default.
• W4378903944 cites W1964938039 @default.
• W4378903944 cites W1972007585 @default.
• W4378903944 cites W1978834568 @default.
• W4378903944 cites W1982939734 @default.
• W4378903944 cites W1992347866 @default.
• W4378903944 cites W1993269816 @default.
• W4378903944 cites W2039836909 @default.
• W4378903944 cites W2040037093 @default.
• W4378903944 cites W2042997964 @default.
• W4378903944 cites W2071126289 @default.
• W4378903944 cites W2073962586 @default.
• W4378903944 cites W2075807755 @default.
• W4378903944 cites W2081295915 @default.
• W4378903944 cites W2096802115 @default.
• W4378903944 cites W2101304900 @default.
• W4378903944 cites W2111875392 @default.
• W4378903944 cites W2115265250 @default.
• W4378903944 cites W2132469628 @default.
• W4378903944 cites W2132470016 @default.
• W4378903944 cites W2132574039 @default.
• W4378903944 cites W2135291457 @default.
• W4378903944 cites W2139193694 @default.
• W4378903944 cites W2149081814 @default.
• W4378903944 cites W2150670693 @default.
• W4378903944 cites W2153114583 @default.
• W4378903944 cites W2161820027 @default.
• W4378903944 cites W2182347908 @default.
• W4378903944 cites W2191797573 @default.
• W4378903944 cites W2282473918 @default.
• W4378903944 cites W2419330183 @default.
• W4378903944 cites W2517615555 @default.
• W4378903944 cites W2566480804 @default.
• W4378903944 cites W2626747973 @default.
• W4378903944 cites W2767736649 @default.
• W4378903944 cites W2784309373 @default.
• W4378903944 cites W2899327468 @default.
• W4378903944 cites W2966429881 @default.
• W4378903944 cites W2973824516 @default.
• W4378903944 cites W2975890503 @default.
• W4378903944 cites W2976449323 @default.
• W4378903944 cites W3008546537 @default.
• W4378903944 cites W3011288781 @default.
• W4378903944 cites W3037249297 @default.
• W4378903944 cites W3112183991 @default.
• W4378903944 cites W3156212197 @default.
• W4378903944 cites W3157560046 @default.
• W4378903944 cites W3162608818 @default.
• W4378903944 cites W3183852984 @default.
• W4378903944 cites W3199156851 @default.
• W4378903944 cites W4200281314 @default.
• W4378903944 cites W4207008330 @default.
• W4378903944 cites W4283743677 @default.
• W4378903944 cites W4285189078 @default.
• W4378903944 cites W4323349534 @default.
• W4378903944 cites W64302408 @default.
• W4378903944 doi "https://doi.org/10.1038/s41598-023-36014-6" @default.
• W4378903944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37258645" @default.
• W4378903944 hasPublicationYear "2023" @default.
• W4378903944 type Work @default.
• W4378903944 citedByCount "0" @default.
• W4378903944 crossrefType "journal-article" @default.
• W4378903944 hasAuthorship W4378903944A5012604646 @default.
• W4378903944 hasAuthorship W4378903944A5040903293 @default.
• W4378903944 hasAuthorship W4378903944A5047037826 @default.
• W4378903944 hasAuthorship W4378903944A5048445694 @default.
• W4378903944 hasAuthorship W4378903944A5067128915 @default.
• W4378903944 hasAuthorship W4378903944A5072875016 @default.
• W4378903944 hasAuthorship W4378903944A5074522090 @default.
• W4378903944 hasAuthorship W4378903944A5083631105 @default.
• W4378903944 hasBestOaLocation W43789039441 @default.
• W4378903944 hasConcept C131872663 @default.
• W4378903944 hasConcept C2779234561 @default.
• W4378903944 hasConcept C2779923321 @default.
• W4378903944 hasConcept C2780673598 @default.
• W4378903944 hasConcept C2911029604 @default.
• W4378903944 hasConcept C29456083 @default.
• W4378903944 hasConcept C54355233 @default.
• W4378903944 hasConcept C71924100 @default.
• W4378903944 hasConcept C80227256 @default.
• W4378903944 hasConcept C86803240 @default.
• W4378903944 hasConceptScore W4378903944C131872663 @default.
• W4378903944 hasConceptScore W4378903944C2779234561 @default.
• W4378903944 hasConceptScore W4378903944C2779923321 @default.

• next