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- W4378907529 abstract "Conjugated oligoelectrolytes (COEs) are amphiphilic, fluorogenic molecules that spontaneously associate with lipid bilayer membranes and are gaining attention as molecular reporters, particularly for exosome detection by flow cytometry. Questions nonetheless remain on how to best design COEs for optimal performance and on the geometry of lipid bilayer intercalation. In response, we designed a series of oligo-phenylenevinylene COEs with varying lengths and numbers of charged groups to address these uncertainties. Examination of the organization within lipid bilayers through polarized fluorescence microscopy shows that the optical transition moments are perpendicular to the bilayer plane, with the conjugated segment flanked by hydrophobic phospholipid tails. COEs initially form a disorganized layer on the vesicle periphery, reflecting electrostatic association before intercalation. Uptake experiments show that longer dimensions and increased numbers of charges allow for a higher degree of cellular association. Both shorter core length and increased number of charges accelerate the rate needed to achieve emission saturation." @default.
- W4378907529 created "2023-06-01" @default.
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- W4378907529 date "2023-06-01" @default.
- W4378907529 modified "2023-09-26" @default.
- W4378907529 title "Molecular orientation and optimization of membrane dyes based on conjugated oligoelectrolytes" @default.
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- W4378907529 doi "https://doi.org/10.1016/j.xcrp.2023.101429" @default.
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