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- W4378908628 endingPage "1597" @default.
- W4378908628 startingPage "1597" @default.
- W4378908628 abstract "Dysfunctional hepatic metabolism has been linked to numerous diseases, including non-alcoholic fatty liver disease, the most common chronic liver disorder worldwide, which can progress to hepatic fibrosis, and is closely associated with insulin resistance and cardiovascular diseases. In addition, the liver secretes a wide array of metabolites, biomolecules, and microRNAs (miRNAs) and many of these secreted factors exert significant effects on metabolic processes both in the liver and in peripheral tissues. In this review, we summarize the involvement of liver-derived miRNAs in biological processes with an emphasis on delineating the communication between the liver and other tissues associated with metabolic disease progression. Furthermore, the review identifies the primary molecular targets by which miRNAs act. These consolidated findings from numerous studies provide insight into the underlying mechanism of various metabolic disease progression and suggest the possibility of using circulatory miRNAs as prognostic predictors and therapeutic targets for improving clinical intervention strategies." @default.
- W4378908628 created "2023-06-01" @default.
- W4378908628 creator A5000471996 @default.
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- W4378908628 creator A5058934067 @default.
- W4378908628 creator A5065416330 @default.
- W4378908628 creator A5086413595 @default.
- W4378908628 date "2023-05-31" @default.
- W4378908628 modified "2023-09-30" @default.
- W4378908628 title "Insight into the Inter-Organ Crosstalk and Prognostic Role of Liver-Derived MicroRNAs in Metabolic Disease Progression" @default.
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