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- W4378952416 abstract "Abstract Astrocytes participate in information processing by releasing neuroactive substances termed gliotransmitters, including ATP. Individual astrocytes come into contact with thousands of synapses with their ramified structure, but the spatiotemporal dynamics of ATP gliotransmission remains unclear, especially in physiological brain tissue. Using a genetically encoded fluorescent sensor, GRAB ATP1.0 , we discovered that extracellular ATP increased locally and transiently in absence of stimuli in neuron–glia co‐cultures, cortical slices, and the anesthetized mouse brain. Spontaneous ATP release events were tetrodotoxin‐insensitive but suppressed by gliotoxin, fluorocitrate, and typically spread over 50–250 μm 2 area at concentrations capable of activating purinergic receptors. Besides, most ATP events did not coincide with Ca 2+ transients, and intracellular Ca 2+ buffering with BAPTA‐AM did not affect ATP event frequency. Clustering analysis revealed that these events followed multiple distinct kinetics, and blockade of exocytosis only decreased a minor group of slow events. Overall, astrocytes spontaneously release ATP through multiple mechanisms, mainly in non‐vesicular and Ca 2+ ‐independent manners, thus potentially regulating hundreds of synapses all together." @default.
- W4378952416 created "2023-06-02" @default.
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- W4378952416 date "2023-06-01" @default.
- W4378952416 modified "2023-10-17" @default.
- W4378952416 title "Spontaneous and multifaceted <scp>ATP</scp> release from astrocytes at the scale of hundreds of synapses" @default.
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- W4378952416 doi "https://doi.org/10.1002/glia.24392" @default.
- W4378952416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37259810" @default.
- W4378952416 hasPublicationYear "2023" @default.