Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378952740> ?p ?o ?g. }
- W4378952740 endingPage "15735" @default.
- W4378952740 startingPage "15720" @default.
- W4378952740 abstract "Gut microbiota plays a significant role in the colorectal cancer (CRC) process. Ectopic colonization of multiple oral bacteria is reportedly associated with CRC pathogenesis and progression, but the details remain unclear.We enrolled a cohort of 50 CRC patients and 52 healthy controls from an East China population. Taxonomic and functional analysis of the fecal microbiota were performed using 16S rDNA (50 + 52 samples) and shotgun metagenomic sequencing (8 + 6 samples), respectively, with particular attention paid to gut-colonized oral bacteria.The results showed more detected bacterial species but lower species evenness within the samples from CRC patients. To determine the specific bacteria enriched in each group, we analyzed their possible protective, carcinogenic, or opportunistic roles in the CRC process. Among the ectopic oral bacteria, we observed a significant increase in the abundance of Fusobacterium and decreased abundance of Prevotella and Ruminococcus in the CRC group. Main differences in the functional composition of these two groups were related to energy metabolism and biosynthesis, especially the glycolytic pathway. Furthermore, we validated the colonization of Fusobacterium nucleatum subsp. animalis within CRC tissues and studied its impact on the host intestinal epithelium and tumor cells. With high selectivity for cancerous tissues, this subspecies promoted CRC cell proliferation and induced potential DNA damage." @default.
- W4378952740 created "2023-06-02" @default.
- W4378952740 creator A5004353749 @default.
- W4378952740 creator A5016183535 @default.
- W4378952740 creator A5040120671 @default.
- W4378952740 creator A5068989040 @default.
- W4378952740 creator A5078705083 @default.
- W4378952740 creator A5088704854 @default.
- W4378952740 creator A5090933878 @default.
- W4378952740 date "2023-06-01" @default.
- W4378952740 modified "2023-09-26" @default.
- W4378952740 title "Disease‐associated gut microbiome and critical metabolomic alterations in patients with colorectal cancer" @default.
- W4378952740 cites W1965907230 @default.
- W4378952740 cites W2010592372 @default.
- W4378952740 cites W2013354102 @default.
- W4378952740 cites W2013362984 @default.
- W4378952740 cites W2021838232 @default.
- W4378952740 cites W2101565190 @default.
- W4378952740 cites W2140145798 @default.
- W4378952740 cites W2169836613 @default.
- W4378952740 cites W2229420368 @default.
- W4378952740 cites W2302003756 @default.
- W4378952740 cites W2472747748 @default.
- W4378952740 cites W2754652167 @default.
- W4378952740 cites W2762107171 @default.
- W4378952740 cites W2762906919 @default.
- W4378952740 cites W2798050410 @default.
- W4378952740 cites W2805950370 @default.
- W4378952740 cites W2885190696 @default.
- W4378952740 cites W2923380089 @default.
- W4378952740 cites W2945192509 @default.
- W4378952740 cites W2950245396 @default.
- W4378952740 cites W2951546814 @default.
- W4378952740 cites W2954905414 @default.
- W4378952740 cites W2969617932 @default.
- W4378952740 cites W2972734154 @default.
- W4378952740 cites W2976007626 @default.
- W4378952740 cites W2991815166 @default.
- W4378952740 cites W2995649573 @default.
- W4378952740 cites W3006497055 @default.
- W4378952740 cites W3014713533 @default.
- W4378952740 cites W3014950179 @default.
- W4378952740 cites W3021119615 @default.
- W4378952740 cites W3022309178 @default.
- W4378952740 cites W3024204649 @default.
- W4378952740 cites W3027118763 @default.
- W4378952740 cites W3048018108 @default.
- W4378952740 cites W3081971156 @default.
- W4378952740 cites W3088828252 @default.
- W4378952740 cites W3090094696 @default.
- W4378952740 cites W3098540694 @default.
- W4378952740 cites W3115125612 @default.
- W4378952740 cites W3119025725 @default.
- W4378952740 cites W3128646645 @default.
- W4378952740 cites W3133921169 @default.
- W4378952740 cites W3134553072 @default.
- W4378952740 cites W3136081418 @default.
- W4378952740 cites W3159685258 @default.
- W4378952740 cites W3165264517 @default.
- W4378952740 cites W3174236237 @default.
- W4378952740 cites W3174825538 @default.
- W4378952740 cites W3181927480 @default.
- W4378952740 cites W3186603088 @default.
- W4378952740 cites W3203464814 @default.
- W4378952740 cites W3208099330 @default.
- W4378952740 cites W3209170136 @default.
- W4378952740 cites W4293920863 @default.
- W4378952740 cites W4296032784 @default.
- W4378952740 cites W4378952740 @default.
- W4378952740 doi "https://doi.org/10.1002/cam4.6194" @default.
- W4378952740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37260140" @default.
- W4378952740 hasPublicationYear "2023" @default.
- W4378952740 type Work @default.
- W4378952740 citedByCount "1" @default.
- W4378952740 countsByYear W43789527402023 @default.
- W4378952740 crossrefType "journal-article" @default.
- W4378952740 hasAuthorship W4378952740A5004353749 @default.
- W4378952740 hasAuthorship W4378952740A5016183535 @default.
- W4378952740 hasAuthorship W4378952740A5040120671 @default.
- W4378952740 hasAuthorship W4378952740A5068989040 @default.
- W4378952740 hasAuthorship W4378952740A5078705083 @default.
- W4378952740 hasAuthorship W4378952740A5088704854 @default.
- W4378952740 hasAuthorship W4378952740A5090933878 @default.
- W4378952740 hasBestOaLocation W43789527401 @default.
- W4378952740 hasConcept C104317684 @default.
- W4378952740 hasConcept C121608353 @default.
- W4378952740 hasConcept C143121216 @default.
- W4378952740 hasConcept C15151743 @default.
- W4378952740 hasConcept C203014093 @default.
- W4378952740 hasConcept C2776202939 @default.
- W4378952740 hasConcept C2777349128 @default.
- W4378952740 hasConcept C2778168646 @default.
- W4378952740 hasConcept C2779676784 @default.
- W4378952740 hasConcept C2780027724 @default.
- W4378952740 hasConcept C2780183776 @default.
- W4378952740 hasConcept C2780423288 @default.
- W4378952740 hasConcept C2780960513 @default.
- W4378952740 hasConcept C2908647359 @default.