Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378952904> ?p ?o ?g. }
- W4378952904 abstract "Abstract While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate the metabolic enzymes and processes that are essential for the resolution of DNA damage. By integrating functional genomics with chromatin proteomics and metabolomics, we provide a detailed description of the interplay between cellular metabolism and the DNA damage response. Further analysis identified that Peroxiredoxin 1, PRDX1, contributes to the DNA damage repair. During the DNA damage response, PRDX1 translocates to the nucleus where it reduces DNA damage‐induced nuclear reactive oxygen species. Moreover, PRDX1 loss lowers aspartate availability, which is required for the DNA damage‐induced upregulation of de novo nucleotide synthesis. In the absence of PRDX1, cells accumulate replication stress and DNA damage, leading to proliferation defects that are exacerbated in the presence of etoposide, thus revealing a role for PRDX1 as a DNA damage surveillance factor." @default.
- W4378952904 created "2023-06-02" @default.
- W4378952904 creator A5004995919 @default.
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- W4378952904 creator A5043898676 @default.
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- W4378952904 creator A5060994993 @default.
- W4378952904 creator A5068363611 @default.
- W4378952904 creator A5083396772 @default.
- W4378952904 date "2023-06-01" @default.
- W4378952904 modified "2023-10-15" @default.
- W4378952904 title "A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability" @default.
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