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- W4378953034 abstract "Age-related macular degeneration (ARMD or AMD) is a progressive, sight-threatening disease. The pathogenesis of ARMD is complex, involving many factors, such as metabolic, functional, genetic, and environmental factors. Recently, long interspersed nuclear element-1 (L1)- mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA (cDNA) has been associated with retinal pigment epithelium (RPE) destruction. These findings provide a strong input for a new direction in the management of ARMD, as certain human immunodeficiency virus (HIV) drugs, such as nucleoside reverse transcriptase inhibitors (NRTIs), were found to suppress inflammation and protect cells of the retina." @default.
- W4378953034 created "2023-06-02" @default.
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- W4378953034 date "2023-11-01" @default.
- W4378953034 modified "2023-09-27" @default.
- W4378953034 title "The Implication of Alu cDNA in the Pathogenesis of ARMD" @default.
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- W4378953034 doi "https://doi.org/10.2174/1874609816666230530095410" @default.
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