FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4378976308> ?p ?o ?g. }

• W4378976308 abstract "Abstract Large-scale prevention of respiratory syncytial virus (RSV) infection may have ecological consequences for co-circulating pathogens, including influenza. We assessed if and for how long RSV infection alters the risk for subsequent influenza infection. We analysed a prospective longitudinal cohort study conducted in South Africa between 2016 and 2018. For participating households, nasopharyngeal samples were taken twice weekly, irrespective of symptoms, across three respiratory virus seasons, and real-time polymerase chain reaction (PCR) was used to identify infection with RSV and/or influenza. We fitted an individual-level hidden markov transmission model in order to estimate RSV and influenza infection rates and their interdependence. Of a total of 122113 samples collected, 1265 (1.0%) were positive for influenza and 1002 (0.8%) positive for RSV, with 15 (0.01%) samples from 12 individuals positive for both influenza and RSV. We observed 2.25-fold higher incidence of co-infection than expected if assuming infections were unrelated. We estimated that infection with influenza is 2.13 (95% CI 0.97 - 4.69) times more likely when already infected with, and for a week following, RSV infection, adjusted for age. This equates to 1.4% of influenza infections that may be attributable to RSV in this population. Due to the local seasonality (RSV season precedes the influenza season), we were unable to estimate changes in RSV infection risk following influenza infection. RSV infection was associated with an increased risk for influenza infection for a short period after infection. However, the impact on population-level transmission dynamics of this individual-level synergistic effect was not measurable in this setting. Research in Context Evidence before this study We searched PubMed titles and abstracts for the terms “influenza”, “RSV” or “Respiratory syncytial virus” and “interaction”, “competition” or “enhancement” resulting in 56 articles, excluding reviews. Evidence for the potential interaction of influenza and RSV originates from analyses of viral surveillance and experimental non-human studies, or isolated mathematical models. Most such studies suggest potential competitive exclusion of RSV and Influenza but are prone to potential confounding and unable to test the links between biological mechanisms and population level impacts. Added value of this study This longitudinal study with frequent testing of participants for colonisation with RSV and Influenza allows sufficient resolution to analyse direct evidence for interaction of both viruses on colonisation. In contrast to evidence insofar we find that the effect of RSV colonisation on the risk for influenza acquisition is short lived and synergistic, but unlikely to substantially effect influenza epidemiology on population level. Implications of all the available evidence RSV infections are likely to have limited impact on influenza circulation." @default.
• W4378976308 created "2023-06-02" @default.
• W4378976308 creator A5003050459 @default.
• W4378976308 creator A5013512208 @default.
• W4378976308 creator A5024517534 @default.
• W4378976308 creator A5036360281 @default.
• W4378976308 creator A5039529915 @default.
• W4378976308 creator A5039960951 @default.
• W4378976308 creator A5040703559 @default.
• W4378976308 creator A5051314999 @default.
• W4378976308 creator A5058553692 @default.
• W4378976308 creator A5073431294 @default.
• W4378976308 creator A5077722265 @default.
• W4378976308 creator A5080719777 @default.
• W4378976308 creator A5086676078 @default.
• W4378976308 date "2023-06-01" @default.
• W4378976308 modified "2023-10-16" @default.
• W4378976308 title "Transient increased risk of influenza infection following RSV infection in South Africa; findings from the PHIRST study, South Africa, 2016-2018" @default.
• W4378976308 cites W1521320051 @default.
• W4378976308 cites W1919480245 @default.
• W4378976308 cites W1968605303 @default.
• W4378976308 cites W2012472812 @default.
• W4378976308 cites W2043933234 @default.
• W4378976308 cites W2077805027 @default.
• W4378976308 cites W2085910808 @default.
• W4378976308 cites W2093596135 @default.
• W4378976308 cites W2109216029 @default.
• W4378976308 cites W2136200005 @default.
• W4378976308 cites W2790140045 @default.
• W4378976308 cites W3150383510 @default.
• W4378976308 cites W3163675987 @default.
• W4378976308 cites W3167986776 @default.
• W4378976308 cites W3174780411 @default.
• W4378976308 cites W3194884695 @default.
• W4378976308 cites W3209071407 @default.
• W4378976308 doi "https://doi.org/10.1101/2023.05.30.23290741" @default.
• W4378976308 hasPublicationYear "2023" @default.
• W4378976308 type Work @default.
• W4378976308 citedByCount "0" @default.
• W4378976308 crossrefType "posted-content" @default.
• W4378976308 hasAuthorship W4378976308A5003050459 @default.
• W4378976308 hasAuthorship W4378976308A5013512208 @default.
• W4378976308 hasAuthorship W4378976308A5024517534 @default.
• W4378976308 hasAuthorship W4378976308A5036360281 @default.
• W4378976308 hasAuthorship W4378976308A5039529915 @default.
• W4378976308 hasAuthorship W4378976308A5039960951 @default.
• W4378976308 hasAuthorship W4378976308A5040703559 @default.
• W4378976308 hasAuthorship W4378976308A5051314999 @default.
• W4378976308 hasAuthorship W4378976308A5058553692 @default.
• W4378976308 hasAuthorship W4378976308A5073431294 @default.
• W4378976308 hasAuthorship W4378976308A5077722265 @default.
• W4378976308 hasAuthorship W4378976308A5080719777 @default.
• W4378976308 hasAuthorship W4378976308A5086676078 @default.
• W4378976308 hasBestOaLocation W43789763081 @default.
• W4378976308 hasConcept C119599485 @default.
• W4378976308 hasConcept C120665830 @default.
• W4378976308 hasConcept C121332964 @default.
• W4378976308 hasConcept C126322002 @default.
• W4378976308 hasConcept C127413603 @default.
• W4378976308 hasConcept C159047783 @default.
• W4378976308 hasConcept C203014093 @default.
• W4378976308 hasConcept C2522874641 @default.
• W4378976308 hasConcept C2777546802 @default.
• W4378976308 hasConcept C2908647359 @default.
• W4378976308 hasConcept C2993183539 @default.
• W4378976308 hasConcept C534529494 @default.
• W4378976308 hasConcept C61511704 @default.
• W4378976308 hasConcept C71924100 @default.
• W4378976308 hasConcept C761482 @default.
• W4378976308 hasConcept C86803240 @default.
• W4378976308 hasConcept C99454951 @default.
• W4378976308 hasConceptScore W4378976308C119599485 @default.
• W4378976308 hasConceptScore W4378976308C120665830 @default.
• W4378976308 hasConceptScore W4378976308C121332964 @default.
• W4378976308 hasConceptScore W4378976308C126322002 @default.
• W4378976308 hasConceptScore W4378976308C127413603 @default.
• W4378976308 hasConceptScore W4378976308C159047783 @default.
• W4378976308 hasConceptScore W4378976308C203014093 @default.
• W4378976308 hasConceptScore W4378976308C2522874641 @default.
• W4378976308 hasConceptScore W4378976308C2777546802 @default.
• W4378976308 hasConceptScore W4378976308C2908647359 @default.
• W4378976308 hasConceptScore W4378976308C2993183539 @default.
• W4378976308 hasConceptScore W4378976308C534529494 @default.
• W4378976308 hasConceptScore W4378976308C61511704 @default.
• W4378976308 hasConceptScore W4378976308C71924100 @default.
• W4378976308 hasConceptScore W4378976308C761482 @default.
• W4378976308 hasConceptScore W4378976308C86803240 @default.
• W4378976308 hasConceptScore W4378976308C99454951 @default.
• W4378976308 hasLocation W43789763081 @default.
• W4378976308 hasOpenAccess W4378976308 @default.
• W4378976308 hasPrimaryLocation W43789763081 @default.
• W4378976308 hasRelatedWork W1487857142 @default.
• W4378976308 hasRelatedWork W2101049386 @default.
• W4378976308 hasRelatedWork W2123630845 @default.
• W4378976308 hasRelatedWork W2137571122 @default.
• W4378976308 hasRelatedWork W2145359412 @default.
• W4378976308 hasRelatedWork W2147629250 @default.
• W4378976308 hasRelatedWork W2162191803 @default.
• W4378976308 hasRelatedWork W2166242021 @default.
• W4378976308 hasRelatedWork W2400613564 @default.

• next