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• W4378976627 abstract "Abstract Exposure to persistent organic pollutants during the perinatal period is of particular concern because of the potential increased risk of neurological disorders in adulthood. Here we questioned whether exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) could alter myelin formation and regeneration. First, we show that PFOS, and to a lesser extent PFOA, accumulated into the myelin sheath of postnatal day 21 (p21) mice, whose mothers were exposed to either PFOA or PFOS (20mg/L) via drinking water during late gestation and lactation, suggesting that accumulation of PFOS into the myelin could interfere with myelin formation and function. In fact, PFOS, but not PFOA, disrupted the generation of oligodendrocytes, the myelin-forming cells of the central nervous system, derived from neural stem cells localised in the subventricular zone of p21 exposed animals. Then, cerebellar slices were transiently demyelinated using lysophosphatidylcholine and remyelination was quantified in the presence of either PFOA or PFOS. Only PFOS impaired remyelination, a deleterious effect rescued by adding thyroid hormone (TH). Similarly to our observation in the mouse, we also showed that PFOS altered remyelination in Xenopus laevis using the Tg( Mbp:GFP-ntr ) model of conditional demyelination and measuring, then, the number of oligodendrocytes. The functional consequences of PFOS-impaired remyelination were shown by its effects using a battery of behavioural tests. In sum, our data demonstrate that perinatal PFOS exposure disrupts oligodendrogenesis and myelin function through modulation of TH action. PFOS exposure may exacerbate genetic and environmental susceptibilities underlying myelin disorders, the most frequent being multiple sclerosis. Highlights Our investigation points the deleterious effects of PFOS incorporation into the myelin sheath PFOS interfere dramatically with the generation of remyelinating and functional repair of demyelinating lesions Our study points to a potential link between these persistent pollutants and the recent increase in prevalence of multiple sclerosis" @default.
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• W4378976627 date "2023-06-01" @default.
• W4378976627 modified "2023-10-18" @default.
• W4378976627 title "Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath" @default.
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• W4378976627 doi "https://doi.org/10.1101/2023.05.30.542807" @default.
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