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- W4378977008 endingPage "113743" @default.
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- W4378977008 abstract "Cordyceps is a genus of ascomycete fungi with some of them being edible and/or having a long tradition in Chinese medicine. The chemical characterization of a solvent extract of the entomopathogenic fungus Cordyceps bifusispora afforded four undescribed coumarins, bifusicoumarin A-D (1–4), along with previously reported metabolites (5–8). Structural elucidation was performed via NMR, UV and HRMS analyses, X-ray single crystal diffraction and experimental ECD. A high throughput resazurin reduction assay, that measures cell viability, indicated that 5 has a IC50 between 1 and 15 μM for several assayed tumor lines. Moreover, a protein-interaction network indicated that C. bifusispora is a promising source of additional antitumor metabolites based on SwissTargetPrediction software predictions." @default.
- W4378977008 created "2023-06-02" @default.
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- W4378977008 date "2023-08-01" @default.
- W4378977008 modified "2023-10-03" @default.
- W4378977008 title "Bifusicoumarins A-D: Cytotoxic 3S-dihydroisocoumarins from the entomopathogenic fungus Cordyceps bifusispora (NBRC 108997)" @default.
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- W4378977008 doi "https://doi.org/10.1016/j.phytochem.2023.113743" @default.
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