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• W4378977452 abstract "In autoreactive germinal centers (GC) initiated by a single rogue B cell clone, wild-type B cells expand and give rise to clones that target other autoantigens, known as epitope spreading. The chronic, progressive nature of epitope spreading calls for early interventions, but the kinetics and molecular requirements for wild-type B cell invasion and participation in GC remain largely unknown. With parabiosis and adoptive transfer approaches in a murine model of systemic lupus erythematosus, we demonstrate that wild-type B cells join existing GCs rapidly, clonally expand, persist, and contribute to autoantibody production and diversification. The invasion of autoreactive GCs required TLR7, B cell receptor specificity, antigen presentation, and type I interferon signaling. The adoptive transfer model provides a novel tool for identifying early events in the breaking of B cell tolerance in autoimmunity.The autoreactive germinal center is an open structure that is susceptible to rapid and persistent naive B cell invasion, with clonal expansion and auto-antibody induction and diversification." @default.
• W4378977452 created "2023-06-02" @default.
• W4378977452 creator A5023578894 @default.
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• W4378977452 date "2023-06-01" @default.
• W4378977452 modified "2023-09-23" @default.
• W4378977452 title "Invasion of spontaneous germinal centers by naive B cells is rapid and persistent" @default.
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• W4378977452 doi "https://doi.org/10.1101/2023.05.30.542805" @default.
• W4378977452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37398148" @default.
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