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- W4378979105 abstract "This Viewpoint identifies some of the pitfalls in the bioavailability of water-soluble drugs and introduces a novel bias we term the “hypohydration bias”. We suggest that future bioavailability studies take some important neglected confounding factors into account, and we propose that, to avoid such a bias, some relevant variables such as serum and urine osmolality, dry weight adjustment, fluid balance, semi-nude body mass, saliva osmolality, saliva total protein concentration, and urine specific gravity should be controlled to increase the precision of the bioavailability measurements. We suggest that a new definition of hydration status is needed, and that systematic protocols of bioavailability studies should be revisited." @default.
- W4378979105 created "2023-06-02" @default.
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- W4378979105 date "2023-06-01" @default.
- W4378979105 modified "2023-09-24" @default.
- W4378979105 title "Inadequate Hydration Status of Test Subjects Can Affect Bioavailability Studies" @default.
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- W4378979105 doi "https://doi.org/10.1021/acsptsci.3c00089" @default.
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