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- W4378980858 abstract "<p>Combination of selinexor and oncolytic MYXV significantly reduced human cancer cells proliferation. <b>A,</b> Schematic representation of the cell proliferation assay protocol using Click-iT EdU kit. <b>B,</b> PANC-1 cells were left untreated (mock) or treated with selinexor, vMyx-GFP or a combination of selinexor + vMyx-GFP and cell proliferation assay was performed using Click-iT EdU kit. The images were taken using a fluorescence microscope. The assays were performed in triplicate and a representative is shown. <b>C,</b> Quantification of the number of cells showing labeling with EdU 594 (red fluorescence). A minimum of 100 cells were used for analysis from fluorescence images taken in <b>B</b>. Data represent mean ± SD and <i>n</i> = 3. Statistically significant differences among the different treatments are indicated. **, <i>P</i> < 0.01; ***, <i>P</i> < 0.001. PANC-1 (<b>D</b> and <b>E</b>) and Colo205 (<b>F</b> and <b>G</b>) cells in 96-well plates were left untreated (mock) or treated with selinexor, vMyx-GFP, a combination of selinexor + vMyx-GFP or vMyx-M11L-KO as control and cell proliferation assay was performed using CyQUANT NF cell proliferation assay kit. Data represent mean ± SD and <i>n</i> = 4. Statistically significant differences among the different treatments are indicated. <sup>ns</sup>, <i>P</i> > 0.05; *, <i>P</i> < 0.05; **, <i>P</i> < 0.01; ***, <i>P</i> < 0.001.</p>" @default.
- W4378980858 created "2023-06-02" @default.
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- W4378980858 date "2023-06-01" @default.
- W4378980858 modified "2023-09-24" @default.
- W4378980858 title "FIGURE 4 from Nuclear Export Inhibitor Selinexor Enhances Oncolytic Myxoma Virus Therapy against Cancer" @default.
- W4378980858 doi "https://doi.org/10.1158/2767-9764.23277096" @default.
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