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• W4379014897 abstract "Dietary supplementation with prebiotic oligosaccharides to modulate the intestinal microbiome has been proposed as a strategy to reduce the risk of necrotising enterocolitis (NEC) and associated mortality and morbidity in very preterm or very low birth weight (VLBW) infants.To assess the benefits and harms of enteral supplementation with prebiotics (versus placebo or no treatment) for preventing NEC and associated morbidity and mortality in very preterm or VLBW infants.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, the Maternity and Infant Care database and the Cumulative Index to Nursing and Allied Health Literature (CINAHL), from the earliest records to July 2022. We searched clinical trials databases and conference proceedings, and examined the reference lists of retrieved articles.We included randomised controlled trials (RCTs) and quasi-RCTs comparing prebiotics with placebo or no prebiotics in very preterm (< 32 weeks' gestation) or VLBW (< 1500 g) infants. The primary outcomes were NEC and all-cause mortality, and the secondary outcomes were late-onset invasive infection, duration of hospitalisation since birth, and neurodevelopmental impairment.Two review authors separately evaluated risk of bias of the trials, extracted data, and synthesised effect estimates using risk ratio (RR), risk difference (RD), and mean difference (MD), with associated 95% confidence intervals (CIs). The primary outcomes of interest were NEC and all-cause mortality; our secondary outcome measures were late-onset (> 48 hours after birth) invasive infection, duration of hospitalisation, and neurodevelopmental impairment. We used the GRADE approach to assess the level of certainty of the evidence.We included seven trials in which a total of 705 infants participated. All the trials were small (mean sample size 100). Lack of clarity on methods to conceal allocation and mask caregivers or investigators were potential sources of bias in three of the trials. The studied prebiotics were fructo- and galacto-oligosaccharides, inulin, and lactulose, typically administered daily with enteral feeds during birth hospitalisation. Meta-analyses of data from seven trials (686 infants) suggest that prebiotics may result in little or no difference in NEC (RR 0.97, 95% CI 0.60 to 1.56; RD none fewer per 1000, 95% CI 50 fewer to 40 more; low-certainty evidence), all-cause mortality (RR 0.43, 95% CI 0.20 to 0.92; 40 per 1000 fewer, 95% CI 70 fewer to none fewer; low-certainty evidence), or late-onset invasive infection (RR 0.79, 95% CI 0.60 to 1.06; 50 per 1000 fewer, 95% CI 100 fewer to 10 more; low-certainty evidence) prior to hospital discharge. The certainty of this evidence is low because of concerns about the risk of bias in some trials and the imprecision of the effect size estimates. The data available from one trial provided only very low-certainty evidence about the effect of prebiotics on measures of neurodevelopmental impairment (Bayley Scales of Infant Development (BSID) Mental Development Index score < 85: RR 0.84, 95% CI 0.25 to 2.90; very low-certainty evidence; BSID Psychomotor Development Index score < 85: RR 0.24, 95% 0.03 to 2.00; very low-certainty evidence; cerebral palsy: RR 0.35, 95% CI 0.01 to 8.35; very low-certainty evidence).The available trial data provide low-certainty evidence about the effects of prebiotics on the risk of NEC, all-cause mortality before discharge, and invasive infection, and very low-certainty evidence about the effect on neurodevelopmental impairment for very preterm or VLBW infants. Our confidence in the effect estimates is limited; the true effects may be substantially different. Large, high-quality trials are needed to provide evidence of sufficient validity to inform policy and practice decisions." @default.
• W4379014897 created "2023-06-02" @default.
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• W4379014897 date "2023-06-01" @default.
• W4379014897 modified "2023-10-11" @default.
• W4379014897 title "Prebiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants" @default.
• W4379014897 cites W1427125429 @default.
• W4379014897 cites W1480377400 @default.
• W4379014897 cites W1522984201 @default.
• W4379014897 cites W1824914325 @default.
• W4379014897 cites W1936997268 @default.
• W4379014897 cites W1966856400 @default.
• W4379014897 cites W1975434115 @default.
• W4379014897 cites W1992597155 @default.
• W4379014897 cites W2004198932 @default.
• W4379014897 cites W2011450737 @default.
• W4379014897 cites W2031395552 @default.
• W4379014897 cites W2036556037 @default.
• W4379014897 cites W2039418122 @default.
• W4379014897 cites W2048184458 @default.
• W4379014897 cites W2057100837 @default.
• W4379014897 cites W2074114437 @default.
• W4379014897 cites W2075520194 @default.
• W4379014897 cites W2076643121 @default.
• W4379014897 cites W2107978987 @default.
• W4379014897 cites W2111583404 @default.
• W4379014897 cites W2122637304 @default.
• W4379014897 cites W2127309960 @default.
• W4379014897 cites W2136734369 @default.
• W4379014897 cites W2136813222 @default.
• W4379014897 cites W2157991180 @default.
• W4379014897 cites W2172259261 @default.
• W4379014897 cites W2203448802 @default.
• W4379014897 cites W2278429137 @default.
• W4379014897 cites W2295620997 @default.
• W4379014897 cites W2319643131 @default.
• W4379014897 cites W2405286020 @default.
• W4379014897 cites W2486735627 @default.
• W4379014897 cites W2519993310 @default.
• W4379014897 cites W2561338758 @default.
• W4379014897 cites W2567362164 @default.
• W4379014897 cites W2588681363 @default.
• W4379014897 cites W2605107433 @default.
• W4379014897 cites W2606166834 @default.
• W4379014897 cites W2612332169 @default.
• W4379014897 cites W2627092521 @default.
• W4379014897 cites W2731811823 @default.
• W4379014897 cites W2734475592 @default.
• W4379014897 cites W2736767459 @default.
• W4379014897 cites W2739899008 @default.
• W4379014897 cites W2782629792 @default.
• W4379014897 cites W2885434293 @default.
• W4379014897 cites W2885599184 @default.
• W4379014897 cites W2889977344 @default.
• W4379014897 cites W2901128045 @default.
• W4379014897 cites W2907933904 @default.
• W4379014897 cites W2908947326 @default.
• W4379014897 cites W2920959640 @default.
• W4379014897 cites W2936161781 @default.
• W4379014897 cites W2945436717 @default.
• W4379014897 cites W2947153686 @default.
• W4379014897 cites W2947616036 @default.
• W4379014897 cites W2948830359 @default.
• W4379014897 cites W2956175090 @default.
• W4379014897 cites W2969935231 @default.
• W4379014897 cites W2971265325 @default.
• W4379014897 cites W2995792428 @default.
• W4379014897 cites W3039778960 @default.
• W4379014897 cites W3049701619 @default.
• W4379014897 cites W3080773717 @default.
• W4379014897 cites W3092321065 @default.
• W4379014897 cites W3093451665 @default.
• W4379014897 cites W3106764389 @default.
• W4379014897 cites W3128472948 @default.
• W4379014897 cites W3153655471 @default.
• W4379014897 cites W3159181740 @default.
• W4379014897 cites W3163141678 @default.
• W4379014897 cites W3167186654 @default.
• W4379014897 cites W3192738879 @default.
• W4379014897 cites W4214630799 @default.
• W4379014897 cites W4224435910 @default.
• W4379014897 cites W4233782998 @default.
• W4379014897 cites W4239021053 @default.
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• W4379014897 doi "https://doi.org/10.1002/14651858.cd015133.pub2" @default.
• W4379014897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37262358" @default.
• W4379014897 hasPublicationYear "2023" @default.
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