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• W4379015641 abstract "Abstract Background Ectopic liver tissue (ELT) is a rare developmental abnormality in which normally functioning liver tissue develops at an extra-hepatic site. Due to the atypical clinical symptoms of ELT, its clinical diagnosis is rarely easy, however, the risk of carcinogenesis is strongly increased due to its special pathological characteristics. So it should always be considered in the differential diagnosis of tumors or symptomatic mass. Case presentation Case 1：A 57-year-old female patient presented herself to the outpatient department of our hospital complaining of paroxysmal upper abdominal pain for one month. She was admitted due to Multiple intrahepatic bile duct stones and chronic cholecystitis. During the surgery, an abnormally enlarged gallbladder of size about 12*8*5cmwas found. A tiny mass of about 1.2*0.6*0.3cm on the free wall of the gallbladder with a similar texture to the liver was also found. Case 2：An 87-year-old male patient presented himself to the emergency department of our hospital complaining of right upper abdomen pain for three days. He was admitted to the hospital due to cholecystolithiasis and chronic cholecystitis. During the surgery, an abnormally enlarged gallbladder of size about 12*8*5cm. A tiny mass of about 1.2*0.6*0.3cm on the free wall of the gallbladder with a similar texture to the liver was also found. After surgery, the two patients are now in good overall condition. Discussion and conclusions In this two continuous cases of Ectopic liver tissue, the pathological examination and liver cancer markers “AFP” and “Glypican-3” did not support tumor lesions. Accordingly, we proposed a new hypothesis for this phenomenon, that cryptogenic functional excretory system (helps to excrete chemical carcinogens) from ELT into the gallbladder (a part of the biliary system) does exist but it cannot be found in ELT located in other organs. This phenomenon may provide a rational response to the question why does Ectopic Liver Tissue on the Gallbladder rarely have malignant transformation." @default.
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• W4379015641 date "2023-06-01" @default.
• W4379015641 modified "2023-10-18" @default.
• W4379015641 title "Why does Ectopic Liver Tissue on the Gallbladder rarely have malignant transformation：Case Series" @default.
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• W4379015641 doi "https://doi.org/10.21203/rs.3.rs-2993713/v1" @default.
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