Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379046906> ?p ?o ?g. }
- W4379046906 endingPage "115098" @default.
- W4379046906 startingPage "115098" @default.
- W4379046906 abstract "As a result of the ban on bisphenol A (BPA), a hormone disruptor with developmental neurotoxicity, several BPA derivatives (BPs) have been widely used in industrial production. However, there are no effective methods for assessing the neurodevelopmental toxic effects of BPs. To address this, a Drosophila exposure model was established, and W1118 was reared in food containing these BPs. Results showed that each BPs displayed different semi-lethal doses ranging from 1.76 to 19.43 mM. Exposure to BPs delayed larval development and affected axonal growth, resulting in the abnormal crossing of the midline of axons in the β lobules of mushroom bodies, but the damage caused by BPE and BPF was relatively minor. BPC, BPAF, and BPAP have the most significant effects on locomotor behavior, whereas BPC exhibited the most affected social interactions. Furthermore, exposure to high-dose BPA, BPC, BPS, BPAF, and BPAP also significantly increased the expression of Drosophila estrogen-related receptors. These demonstrated that different kinds of BPs had different levels of neurodevelopmental toxicity, and the severity was BPZ > BPC and BPAF > BPB > BPS > BPAP ≈ BPAl ≈ BPF > BPE. Therefore, BPZ, BPC, BPS, BPAF, and BPAP should be evaluated as potential alternatives to BPA." @default.
- W4379046906 created "2023-06-02" @default.
- W4379046906 creator A5007696681 @default.
- W4379046906 creator A5015315809 @default.
- W4379046906 creator A5030064573 @default.
- W4379046906 creator A5035922486 @default.
- W4379046906 creator A5044053727 @default.
- W4379046906 creator A5051454432 @default.
- W4379046906 creator A5075877965 @default.
- W4379046906 date "2023-07-01" @default.
- W4379046906 modified "2023-09-24" @default.
- W4379046906 title "Developmental neurotoxic effects of bisphenol A and its derivatives in Drosophila melanogaster" @default.
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