Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379056549> ?p ?o ?g. }
- W4379056549 endingPage "1632" @default.
- W4379056549 startingPage "1632" @default.
- W4379056549 abstract "The increasing number of skin cancer cases worldwide and the adverse side effects of current treatments have led to the search for new anticancer agents. In this present work, the anticancer potential of the natural flavanone 1, extracted from Eysenhardtia platycarpa, and four flavanone derivatives 1a-d obtained by different reactions from 1 was investigated by an in silico study and through cytotoxicity assays in melanoma (M21), cervical cancer (HeLa) cell lines and in a non-tumor cell line (HEK-293). The free compounds and compounds loaded in biopolymeric nanoparticles (PLGA NPs 1, 1a-d) were assayed. A structure-activity study (SAR) was performed to establish the main physicochemical characteristics that most contribute to cytotoxicity. Finally, ex vivo permeation studies were performed to assess the suitability of the flavanones for topical administration. Results revealed that most of the studied flavanones and their respective PLGA NPs inhibited cell growth depending on the concentration; 1b should be highlighted. The descriptors of the energetic factor were those that played a more important role in cellular activity. PLGA NPs demonstrated their ability to penetrate (Qp of 17.84-118.29 µg) and be retained (Qr of 0.01-1.44 g/gskin/cm2) in the skin and to exert their action for longer. The results of the study suggest that flavanones could offer many opportunities as a future anticancer topical adjuvant treatment." @default.
- W4379056549 created "2023-06-02" @default.
- W4379056549 creator A5015153813 @default.
- W4379056549 creator A5019671472 @default.
- W4379056549 creator A5048919158 @default.
- W4379056549 creator A5049156747 @default.
- W4379056549 creator A5064049384 @default.
- W4379056549 creator A5067238059 @default.
- W4379056549 creator A5071058898 @default.
- W4379056549 creator A5084159010 @default.
- W4379056549 date "2023-05-31" @default.
- W4379056549 modified "2023-10-18" @default.
- W4379056549 title "In Vitro Approaches to Explore the Anticancer Potential of One Natural Flavanone and Four Derivatives Loaded in Biopolymeric Nanoparticles for Application in Topical Delivery Treatments" @default.
- W4379056549 cites W1970442695 @default.
- W4379056549 cites W1976606354 @default.
- W4379056549 cites W1993317648 @default.
- W4379056549 cites W1997872815 @default.
- W4379056549 cites W2001319395 @default.
- W4379056549 cites W2021005040 @default.
- W4379056549 cites W2035581397 @default.
- W4379056549 cites W2042640674 @default.
- W4379056549 cites W2085450446 @default.
- W4379056549 cites W2121939023 @default.
- W4379056549 cites W2160340213 @default.
- W4379056549 cites W2491846319 @default.
- W4379056549 cites W2595952395 @default.
- W4379056549 cites W2755055188 @default.
- W4379056549 cites W2770422119 @default.
- W4379056549 cites W2776030832 @default.
- W4379056549 cites W2881923384 @default.
- W4379056549 cites W2889708206 @default.
- W4379056549 cites W2901824970 @default.
- W4379056549 cites W2907688525 @default.
- W4379056549 cites W2908176514 @default.
- W4379056549 cites W2921300640 @default.
- W4379056549 cites W2944932175 @default.
- W4379056549 cites W2946412700 @default.
- W4379056549 cites W2952806785 @default.
- W4379056549 cites W2958586634 @default.
- W4379056549 cites W2965932727 @default.
- W4379056549 cites W2967057123 @default.
- W4379056549 cites W2973131212 @default.
- W4379056549 cites W2987691085 @default.
- W4379056549 cites W2997202913 @default.
- W4379056549 cites W3002151734 @default.
- W4379056549 cites W3005533031 @default.
- W4379056549 cites W3006849631 @default.
- W4379056549 cites W3033415079 @default.
- W4379056549 cites W3034391802 @default.
- W4379056549 cites W3082410615 @default.
- W4379056549 cites W3121858355 @default.
- W4379056549 cites W3128640783 @default.
- W4379056549 cites W3158350731 @default.
- W4379056549 cites W3183452167 @default.
- W4379056549 cites W3195190752 @default.
- W4379056549 cites W3208115225 @default.
- W4379056549 cites W3211660962 @default.
- W4379056549 cites W4214600812 @default.
- W4379056549 cites W4281639880 @default.
- W4379056549 cites W4283575784 @default.
- W4379056549 cites W4289313888 @default.
- W4379056549 doi "https://doi.org/10.3390/pharmaceutics15061632" @default.
- W4379056549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37376079" @default.
- W4379056549 hasPublicationYear "2023" @default.
- W4379056549 type Work @default.
- W4379056549 citedByCount "1" @default.
- W4379056549 countsByYear W43790565492023 @default.
- W4379056549 crossrefType "journal-article" @default.
- W4379056549 hasAuthorship W4379056549A5015153813 @default.
- W4379056549 hasAuthorship W4379056549A5019671472 @default.
- W4379056549 hasAuthorship W4379056549A5048919158 @default.
- W4379056549 hasAuthorship W4379056549A5049156747 @default.
- W4379056549 hasAuthorship W4379056549A5064049384 @default.
- W4379056549 hasAuthorship W4379056549A5067238059 @default.
- W4379056549 hasAuthorship W4379056549A5071058898 @default.
- W4379056549 hasAuthorship W4379056549A5084159010 @default.
- W4379056549 hasBestOaLocation W43790565491 @default.
- W4379056549 hasConcept C109316439 @default.
- W4379056549 hasConcept C150903083 @default.
- W4379056549 hasConcept C185592680 @default.
- W4379056549 hasConcept C202751555 @default.
- W4379056549 hasConcept C203014093 @default.
- W4379056549 hasConcept C207001950 @default.
- W4379056549 hasConcept C2777366897 @default.
- W4379056549 hasConcept C2777481717 @default.
- W4379056549 hasConcept C2777863537 @default.
- W4379056549 hasConcept C2778004101 @default.
- W4379056549 hasConcept C2779054382 @default.
- W4379056549 hasConcept C55493867 @default.
- W4379056549 hasConcept C71924100 @default.
- W4379056549 hasConcept C86803240 @default.
- W4379056549 hasConcept C98274493 @default.
- W4379056549 hasConceptScore W4379056549C109316439 @default.
- W4379056549 hasConceptScore W4379056549C150903083 @default.
- W4379056549 hasConceptScore W4379056549C185592680 @default.
- W4379056549 hasConceptScore W4379056549C202751555 @default.
- W4379056549 hasConceptScore W4379056549C203014093 @default.
- W4379056549 hasConceptScore W4379056549C207001950 @default.