Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379094259> ?p ?o ?g. }
- W4379094259 endingPage "471" @default.
- W4379094259 startingPage "445" @default.
- W4379094259 abstract "Significance: Redox and epigenetics are two important regulatory processes of cell physiological functions. The cross-regulation between these processes has critical effects on the occurrence and development of various types of tumors. Recent Advances: The core factor that influences redox balance is reactive oxygen species (ROS) generation. ROS functions as a double-edged sword in tumors: low levels of ROS promote tumors, whereas excessive ROS induces various forms of tumor cell death, including apoptosis and ferroptosis as well as necroptosis and pyroptosis. Many studies have shown that the redox balance is influenced by epigenetic mechanisms such as DNA methylation, histone modification, chromatin remodeling, non-coding RNAs (microRNA, long non-coding RNA, and circular RNA), and RNA N6-methyladenosine modification. Several oxidizing or reducing substances also affect the epigenetic state. Critical Issues: In this review, we summarize research on the cross-regulation between redox and epigenetics in cancer and discuss the relevant molecular mechanisms. We also discuss the current research on the clinical applications. Future Directions: Future research can use high-throughput methods to analyze the molecular mechanisms of the cross-regulation between redox and epigenetics using in in vitro and in vivo models in more detail, elucidate regulatory mechanisms, and provide guidance for clinical treatment." @default.
- W4379094259 created "2023-06-03" @default.
- W4379094259 creator A5002318539 @default.
- W4379094259 creator A5046846944 @default.
- W4379094259 creator A5062475481 @default.
- W4379094259 date "2023-09-01" @default.
- W4379094259 modified "2023-10-16" @default.
- W4379094259 title "Cross-regulation between redox and epigenetic systems in tumorigenesis: molecular mechanisms and clinical applications" @default.
- W4379094259 cites W1871976549 @default.
- W4379094259 cites W1970150191 @default.
- W4379094259 cites W1972553181 @default.
- W4379094259 cites W1974000457 @default.
- W4379094259 cites W1986814961 @default.
- W4379094259 cites W1997183854 @default.
- W4379094259 cites W2001422326 @default.
- W4379094259 cites W2002490399 @default.
- W4379094259 cites W2004556005 @default.
- W4379094259 cites W2008769095 @default.
- W4379094259 cites W2008901235 @default.
- W4379094259 cites W2019124202 @default.
- W4379094259 cites W2038235796 @default.
- W4379094259 cites W2043476229 @default.
- W4379094259 cites W2050377050 @default.
- W4379094259 cites W2077236650 @default.
- W4379094259 cites W2085861651 @default.
- W4379094259 cites W2088012387 @default.
- W4379094259 cites W2088911685 @default.
- W4379094259 cites W2090678665 @default.
- W4379094259 cites W2096083625 @default.
- W4379094259 cites W2098131661 @default.
- W4379094259 cites W2105345155 @default.
- W4379094259 cites W2107955209 @default.
- W4379094259 cites W2108164249 @default.
- W4379094259 cites W2128625686 @default.
- W4379094259 cites W2152398648 @default.
- W4379094259 cites W2161326542 @default.
- W4379094259 cites W2163622835 @default.
- W4379094259 cites W2169895170 @default.
- W4379094259 cites W2265062179 @default.
- W4379094259 cites W2276699143 @default.
- W4379094259 cites W2409811039 @default.
- W4379094259 cites W2415723614 @default.
- W4379094259 cites W2415854929 @default.
- W4379094259 cites W2417426823 @default.
- W4379094259 cites W2510146214 @default.
- W4379094259 cites W2511667040 @default.
- W4379094259 cites W2512886987 @default.
- W4379094259 cites W2527636586 @default.
- W4379094259 cites W2546967042 @default.
- W4379094259 cites W2547557128 @default.
- W4379094259 cites W2549188196 @default.
- W4379094259 cites W2550564089 @default.
- W4379094259 cites W2564167988 @default.
- W4379094259 cites W2581841075 @default.
- W4379094259 cites W2585340283 @default.
- W4379094259 cites W2586088194 @default.
- W4379094259 cites W2587544916 @default.
- W4379094259 cites W2588025094 @default.
- W4379094259 cites W2592106274 @default.
- W4379094259 cites W2611475096 @default.
- W4379094259 cites W2611800801 @default.
- W4379094259 cites W2614855056 @default.
- W4379094259 cites W2621333085 @default.
- W4379094259 cites W2625600561 @default.
- W4379094259 cites W2747424453 @default.
- W4379094259 cites W2751584225 @default.
- W4379094259 cites W2759946119 @default.
- W4379094259 cites W2762049913 @default.
- W4379094259 cites W2762087180 @default.
- W4379094259 cites W2772792536 @default.
- W4379094259 cites W2778620777 @default.
- W4379094259 cites W2794021749 @default.
- W4379094259 cites W2794716730 @default.
- W4379094259 cites W2794902297 @default.
- W4379094259 cites W2795121593 @default.
- W4379094259 cites W2890140563 @default.
- W4379094259 cites W2890597423 @default.
- W4379094259 cites W2890626270 @default.
- W4379094259 cites W2895588157 @default.
- W4379094259 cites W2896053120 @default.
- W4379094259 cites W2910561108 @default.
- W4379094259 cites W2911958258 @default.
- W4379094259 cites W2916543168 @default.
- W4379094259 cites W2944417415 @default.
- W4379094259 cites W2946740283 @default.
- W4379094259 cites W2952099132 @default.
- W4379094259 cites W2952125490 @default.
- W4379094259 cites W2953465845 @default.
- W4379094259 cites W2964069817 @default.
- W4379094259 cites W2969571416 @default.
- W4379094259 cites W2973624765 @default.
- W4379094259 cites W2977026913 @default.
- W4379094259 cites W2979937337 @default.
- W4379094259 cites W2980411115 @default.
- W4379094259 cites W2982979216 @default.
- W4379094259 cites W2995898384 @default.
- W4379094259 cites W3000246387 @default.
- W4379094259 cites W3002823891 @default.