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• W4379094792 abstract "Abstract Objective Neurosurgery is a safe and effective form of treatment for select children with drug‐resistant epilepsy. Still, there is concern that it remains underutilized, and that seizure freedom rates have not improved over time. We investigated referral and surgical practices, patient characteristics, and postoperative outcomes over the past two decades. Methods We performed a retrospective cohort study of children referred for epilepsy surgery at a tertiary center between 2000 and 2018. We extracted information from medical records and analyzed temporal trends using regression analyses. Results A total of 1443 children were evaluated for surgery. Of these, 859 (402 females) underwent surgical resection or disconnection at a median age of 8.5 years (interquartile range [IQR] = 4.6–13.4). Excluding palliative procedures, 67% of patients were seizure‐free and 15% were on no antiseizure medication (ASM) at 1‐year follow‐up. There was an annual increase in the number of referrals (7%, 95% confidence interval [CI] = 5.3–8.6; p < .001) and surgeries (4% [95% CI = 2.9–5.6], p < .001) over time. Duration of epilepsy and total number of different ASMs trialed from epilepsy onset to surgery were, however, unchanged, and continued to exceed guidelines. Seizure freedom rates were also unchanged overall but showed improvement (odds ratio [OR] 1.09, 95% CI = 1.01–1.18; p = .027) after adjustment for an observed increase in complex cases. Children who underwent surgery more recently were more likely to be off ASMs postoperatively (OR 1.04, 95% CI = 1.01–1.08; p = .013). There was a 17% annual increase (95% CI = 8.4–28.4, p < .001) in children identified to have a genetic cause of epilepsy, which was associated with poor outcome. Significance Children with drug‐resistant epilepsy continue to be put forward for surgery late, despite national and international guidelines urging prompt referral. Seizure freedom rates have improved over the past decades, but only after adjustment for a concurrent increase in complex cases. Finally, genetic testing in epilepsy surgery patients has expanded considerably over time and shows promise in identifying patients in whom surgery is less likely to be successful." @default.
• W4379094792 created "2023-06-03" @default.
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• W4379094792 date "2023-07-21" @default.
• W4379094792 modified "2023-10-16" @default.
• W4379094792 title "Pediatric epilepsy surgery from 2000 to 2018: Changes in referral and surgical volumes, patient characteristics, genetic testing, and postsurgical outcomes" @default.
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• W4379094792 doi "https://doi.org/10.1111/epi.17670" @default.
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