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- W4379106395 abstract "Abstract The serotonergic system plays important roles in both physiological and pathological processes, and is a widely used therapeutic target for many psychiatric disorders. Although several genetically encoded GFP-based serotonin (5-HT) sensors were recently developed, their sensitivities and spectral profiles are relatively limited. To overcome these limitations, we optimized green fluorescent G-protein-coupled receptor (GPCR)-activation-based 5-HT (GRAB 5-HT ) sensors and developed a new red fluorescent GRAB 5-HT sensor. These sensors have excellent cell surface trafficking, high specificity, sensitivity, and spatiotemporal resolution, making them suitable for monitoring 5-HT dynamics in vivo . Besides recording subcortical 5-HT release in freely moving mice, we observed both uniform and gradient 5-HT release in the mouse dorsal cortex with mesoscopic imaging. Finally, we performed dual-color imaging and observed seizure-induced waves of 5-HT release throughout the cortex following calcium and endocannabinoid waves. In summary, these 5-HT sensors can offer valuable insights regarding the serotonergic system in both physiological and pathological states." @default.
- W4379106395 created "2023-06-03" @default.
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- W4379106395 date "2023-05-30" @default.
- W4379106395 modified "2023-09-27" @default.
- W4379106395 title "Dual-color GRAB sensors for monitoring spatiotemporal serotonin release<i>in vivo</i>" @default.
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- W4379106395 doi "https://doi.org/10.1101/2023.05.27.542566" @default.
- W4379106395 hasPublicationYear "2023" @default.
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