Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379113783> ?p ?o ?g. }
- W4379113783 abstract "Sleep loss typically imposes negative effects on animal health. However, humans with a rare genetic mutation in the dec2 gene ( dec2P384R ) present an exception; these individuals sleep less without the usual effects associated with sleep deprivation. Thus, it has been suggested that the dec2P384R mutation activates compensatory mechanisms that allows these individuals to thrive with less sleep. To test this directly, we used a Drosophila model to study the effects of the dec2P384R mutation on animal health. Expression of human dec2P384R in fly sleep neurons was sufficient to mimic the short sleep phenotype and, remarkably, dec2P384R mutants lived significantly longer with improved health despite sleeping less. The improved physiological effects were enabled, in part, by enhanced mitochondrial fitness and upregulation of multiple stress response pathways. Moreover, we provide evidence that upregulation of pro-health pathways also contributes to the short sleep phenotype, and this phenomenon may extend to other pro-longevity models." @default.
- W4379113783 created "2023-06-03" @default.
- W4379113783 creator A5016915359 @default.
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- W4379113783 date "2023-06-02" @default.
- W4379113783 modified "2023-09-27" @default.
- W4379113783 title "A familial natural short sleep mutation promotes healthy aging and extends lifespan in Drosophila" @default.
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