FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379142175> ?p ?o ?g. }

• W4379142175 abstract "This study explored the ability of plasma amyloid beta (Aβ)42/Aβ40 to identify brain amyloid deposition in cognitively unimpaired (CU) individuals.Plasma Aβ was quantified with an antibody-free high-performance liquid chromatography tandem mass spectrometry method from Araclon Biotech (ABtest-MS) in a subset of 731 CU individuals from the screening visit of the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) Study, to assess associations of Aβ42/Aβ40 with Aβ positron emission tomography (PET).A model including Aβ42/Aβ40, age, apolipoprotein E ε4, and recruitment site identified Aβ PET status with an area under the curve of 0.88 and an overall accuracy of 81%. A plasma-based pre-screening step could save up to 42% of the total number of Aβ PET scans.ABtest-MS accurately identified brain amyloid deposition in a population of CU individuals, supporting its implementation in AD secondary prevention trials to reduce recruitment time and costs. Although a certain degree of heterogeneity is inherent to large and multicentric trials, ABtest-MS could be more robust to pre-analytical bias compared to other immunoprecipitation mass spectrometry methods.Plasma amyloid beta (Aβ)42/Aβ40 accurately identified brain Aβ deposition in cognitively unimpaired individuals from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) Study.The inclusion of the recruitment site in the predictive models has a non-negligible effect.A plasma biomarker-based model could reduce recruitment costs in Alzheimer's disease secondary prevention trials.Antibody-free liquid chromatography mass spectrometry methods may be more robust to pre-analytical variability than other platforms." @default.
• W4379142175 created "2023-06-03" @default.
• W4379142175 creator A5019285186 @default.
• W4379142175 creator A5029554092 @default.
• W4379142175 creator A5031148071 @default.
• W4379142175 creator A5035987097 @default.
• W4379142175 creator A5039917494 @default.
• W4379142175 creator A5048460948 @default.
• W4379142175 creator A5068905678 @default.
• W4379142175 creator A5074129724 @default.
• W4379142175 creator A5089944976 @default.
• W4379142175 date "2023-04-01" @default.
• W4379142175 modified "2023-09-26" @default.
• W4379142175 title "Clinical utility of an antibody‐free LC‐MS method to detect brain amyloid deposition in cognitively unimpaired individuals from the screening visit of the A4 Study" @default.
• W4379142175 cites W1585653286 @default.
• W4379142175 cites W1761228750 @default.
• W4379142175 cites W1804731458 @default.
• W4379142175 cites W2016787780 @default.
• W4379142175 cites W2051737015 @default.
• W4379142175 cites W2112579276 @default.
• W4379142175 cites W2113092554 @default.
• W4379142175 cites W2115738813 @default.
• W4379142175 cites W2131261046 @default.
• W4379142175 cites W2142635246 @default.
• W4379142175 cites W2592503176 @default.
• W4379142175 cites W2750795037 @default.
• W4379142175 cites W2884982789 @default.
• W4379142175 cites W2888674814 @default.
• W4379142175 cites W2901825772 @default.
• W4379142175 cites W2932040131 @default.
• W4379142175 cites W2943469513 @default.
• W4379142175 cites W2966365568 @default.
• W4379142175 cites W2968099105 @default.
• W4379142175 cites W2970537246 @default.
• W4379142175 cites W2995630198 @default.
• W4379142175 cites W2995724321 @default.
• W4379142175 cites W3014487247 @default.
• W4379142175 cites W3016796793 @default.
• W4379142175 cites W3093943691 @default.
• W4379142175 cites W3104533249 @default.
• W4379142175 cites W3107392275 @default.
• W4379142175 cites W3118303681 @default.
• W4379142175 cites W3157305846 @default.
• W4379142175 cites W3174265554 @default.
• W4379142175 cites W3203425241 @default.
• W4379142175 cites W3206830763 @default.
• W4379142175 cites W3214939633 @default.
• W4379142175 cites W3214993261 @default.
• W4379142175 cites W4205799296 @default.
• W4379142175 cites W4206250670 @default.
• W4379142175 cites W4210357094 @default.
• W4379142175 cites W4224253520 @default.
• W4379142175 cites W4225589542 @default.
• W4379142175 cites W4226166104 @default.
• W4379142175 cites W4285088596 @default.
• W4379142175 cites W4288987676 @default.
• W4379142175 cites W4290603418 @default.
• W4379142175 cites W4296249578 @default.
• W4379142175 cites W4297036157 @default.
• W4379142175 cites W4308773890 @default.
• W4379142175 cites W4313559631 @default.
• W4379142175 cites W4317840374 @default.
• W4379142175 doi "https://doi.org/10.1002/dad2.12451" @default.
• W4379142175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37274930" @default.
• W4379142175 hasPublicationYear "2023" @default.
• W4379142175 type Work @default.
• W4379142175 citedByCount "0" @default.
• W4379142175 crossrefType "journal-article" @default.
• W4379142175 hasAuthorship W4379142175A5019285186 @default.
• W4379142175 hasAuthorship W4379142175A5029554092 @default.
• W4379142175 hasAuthorship W4379142175A5031148071 @default.
• W4379142175 hasAuthorship W4379142175A5035987097 @default.
• W4379142175 hasAuthorship W4379142175A5039917494 @default.
• W4379142175 hasAuthorship W4379142175A5048460948 @default.
• W4379142175 hasAuthorship W4379142175A5068905678 @default.
• W4379142175 hasAuthorship W4379142175A5074129724 @default.
• W4379142175 hasAuthorship W4379142175A5089944976 @default.
• W4379142175 hasBestOaLocation W43791421751 @default.
• W4379142175 hasConcept C126322002 @default.
• W4379142175 hasConcept C142724271 @default.
• W4379142175 hasConcept C143998085 @default.
• W4379142175 hasConcept C15744967 @default.
• W4379142175 hasConcept C159654299 @default.
• W4379142175 hasConcept C185592680 @default.
• W4379142175 hasConcept C203014093 @default.
• W4379142175 hasConcept C2775842073 @default.
• W4379142175 hasConcept C2776156579 @default.
• W4379142175 hasConcept C2777633098 @default.
• W4379142175 hasConcept C2777910003 @default.
• W4379142175 hasConcept C2779134260 @default.
• W4379142175 hasConcept C2781197716 @default.
• W4379142175 hasConcept C2989005 @default.
• W4379142175 hasConcept C502032728 @default.
• W4379142175 hasConcept C55493867 @default.
• W4379142175 hasConcept C71924100 @default.
• W4379142175 hasConceptScore W4379142175C126322002 @default.
• W4379142175 hasConceptScore W4379142175C142724271 @default.
• W4379142175 hasConceptScore W4379142175C143998085 @default.
• W4379142175 hasConceptScore W4379142175C15744967 @default.
• W4379142175 hasConceptScore W4379142175C159654299 @default.

• next