Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379184489> ?p ?o ?g. }
- W4379184489 endingPage "e0286633" @default.
- W4379184489 startingPage "e0286633" @default.
- W4379184489 abstract "The aim of this work is to quantify the metabolic profile of the human putamen in vivo in a cohort of elderly subjects using single-voxel proton magnetic resonance spectroscopy. To obtain metabolite concentrations specific to the putamen, we investigated a correction method previously proposed to account for the tissue composition of the volume of interest. We compared the method with the conventional approach, which a priori assumes equal metabolite concentrations in GM and WM. Finally, we compared the concentrations acquired at 3 Tesla (T) and 7 T MRI scanners. Spectra were acquired from 15 subjects (age: 67.7 ± 8.3 years) at 3 T and 7 T, using an ultra-short echo time, stimulated echo acquisition mode sequence. To robustly estimate the WM-to-GM metabolite concentration ratio, five additional subjects were measured for whom the MRS voxel was deliberately shifted from the putamen in order to increase the covered amount of surrounding WM. The concentration and WM-to-GM concentration ratio for 16 metabolites were reliably estimated. These ratios ranged from ~0.3 for γ-aminobutyric acid to ~4 for N-acetylaspartylglutamate. The investigated correction method led to significant changes in concentrations compared to the conventional method, provided that the ratio significantly differed from unity. Finally, we demonstrated that differences in tissue voxel composition cannot fully account for the observed concentration difference between field strengths. We provide not only a fully comprehensive quantification of the neurochemical profile of the putamen in elderly subjects, but also a quantification of the WM-to-GM concentration ratio. This knowledge may serve as a basis for future studies with varying tissue voxel composition, either due to tissue atrophy, inconsistent voxel positioning or simply when pooling data from different voxel locations." @default.
- W4379184489 created "2023-06-03" @default.
- W4379184489 creator A5000309229 @default.
- W4379184489 creator A5008040034 @default.
- W4379184489 creator A5009975920 @default.
- W4379184489 creator A5025827594 @default.
- W4379184489 creator A5071643772 @default.
- W4379184489 creator A5080852796 @default.
- W4379184489 date "2023-06-02" @default.
- W4379184489 modified "2023-09-27" @default.
- W4379184489 title "Quantification of the neurochemical profile of the human putamen using STEAM MRS in a cohort of elderly subjects at 3 T and 7 T: Ruminations on the correction strategy for the tissue voxel composition" @default.
- W4379184489 cites W100874293 @default.
- W4379184489 cites W1524422590 @default.
- W4379184489 cites W1639707408 @default.
- W4379184489 cites W1672528357 @default.
- W4379184489 cites W1830318790 @default.
- W4379184489 cites W1840945875 @default.
- W4379184489 cites W1898260630 @default.
- W4379184489 cites W1901260206 @default.
- W4379184489 cites W1907949022 @default.
- W4379184489 cites W1922488318 @default.
- W4379184489 cites W1932945847 @default.
- W4379184489 cites W1965026504 @default.
- W4379184489 cites W1965059554 @default.
- W4379184489 cites W1966105187 @default.
- W4379184489 cites W1973609741 @default.
- W4379184489 cites W1976169753 @default.
- W4379184489 cites W1978791955 @default.
- W4379184489 cites W1982325931 @default.
- W4379184489 cites W1986075540 @default.
- W4379184489 cites W1987887348 @default.
- W4379184489 cites W1990301502 @default.
- W4379184489 cites W1991470254 @default.
- W4379184489 cites W1994958750 @default.
- W4379184489 cites W1995653322 @default.
- W4379184489 cites W1998185086 @default.
- W4379184489 cites W2001399554 @default.
- W4379184489 cites W2004807720 @default.
- W4379184489 cites W2017241114 @default.
- W4379184489 cites W2037463060 @default.
- W4379184489 cites W2038979894 @default.
- W4379184489 cites W2039472465 @default.
- W4379184489 cites W2045290032 @default.
- W4379184489 cites W2048052925 @default.
- W4379184489 cites W2049112858 @default.
- W4379184489 cites W2051607590 @default.
- W4379184489 cites W2058535112 @default.
- W4379184489 cites W2061225934 @default.
- W4379184489 cites W2072415740 @default.
- W4379184489 cites W2072972701 @default.
- W4379184489 cites W2073576352 @default.
- W4379184489 cites W2075789321 @default.
- W4379184489 cites W2076681561 @default.
- W4379184489 cites W2076745091 @default.
- W4379184489 cites W2088315332 @default.
- W4379184489 cites W2089363653 @default.
- W4379184489 cites W2089940272 @default.
- W4379184489 cites W2094806572 @default.
- W4379184489 cites W2105552075 @default.
- W4379184489 cites W2109195157 @default.
- W4379184489 cites W2114235505 @default.
- W4379184489 cites W2127421809 @default.
- W4379184489 cites W2132482394 @default.
- W4379184489 cites W2132562673 @default.
- W4379184489 cites W2135719766 @default.
- W4379184489 cites W2136573752 @default.
- W4379184489 cites W2136772194 @default.
- W4379184489 cites W2136944400 @default.
- W4379184489 cites W2145748900 @default.
- W4379184489 cites W2147109230 @default.
- W4379184489 cites W2148944280 @default.
- W4379184489 cites W2153202389 @default.
- W4379184489 cites W2157784344 @default.
- W4379184489 cites W2158514967 @default.
- W4379184489 cites W2159680142 @default.
- W4379184489 cites W2166942564 @default.
- W4379184489 cites W2168407651 @default.
- W4379184489 cites W2168709353 @default.
- W4379184489 cites W2171928025 @default.
- W4379184489 cites W2185421735 @default.
- W4379184489 cites W2231941418 @default.
- W4379184489 cites W2279193171 @default.
- W4379184489 cites W2281092316 @default.
- W4379184489 cites W2520432605 @default.
- W4379184489 cites W2527894474 @default.
- W4379184489 cites W2583406573 @default.
- W4379184489 cites W2610163897 @default.
- W4379184489 cites W2616359465 @default.
- W4379184489 cites W2735799337 @default.
- W4379184489 cites W2751760087 @default.
- W4379184489 cites W2801427800 @default.
- W4379184489 cites W2889541545 @default.
- W4379184489 cites W2897834681 @default.
- W4379184489 cites W2902785078 @default.
- W4379184489 cites W2911994974 @default.
- W4379184489 cites W2932841619 @default.
- W4379184489 cites W2946084536 @default.
- W4379184489 cites W2993277982 @default.