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- W4379207863 abstract "Skin cancer is diagnosed in nearly 1.5 million patients each year (1). While patients with basal and squamous cell carcinomas are provided with 5-year survival rates at nearly 100% and 90%, respectively, patients diagnosed with cutaneous melanoma (metastatic melanoma) are provided 5-year survival rates at 91.4% at stage I and 24.6% at stage IV (2-5). We mined public and published microarray datasets (6, 7) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the deadliest type of skin cancer, malignant melanoma. We found significant differential expression of the gene encoding fasciculation and elongation protein zeta 1, FEZ1, when comparing melanoma cell line gene expression to normal human melanocytes. FEZ1 mRNA was present at significantly lower quantities in melanoma cell cultures as compared to normal melanocytes. Analysis of human survival data revealed that expression of FEZ1 in melanoma tissues was correlated with overall survival in patients with malignant melanoma. FEZ1 expression changes may be important for the initiation or progression of malignant melanoma in humans." @default.
- W4379207863 created "2023-06-04" @default.
- W4379207863 creator A5024900493 @default.
- W4379207863 date "2023-06-02" @default.
- W4379207863 modified "2023-10-17" @default.
- W4379207863 title "Differential expression of FEZ1 in cancer of the skin: malignant melanoma." @default.
- W4379207863 doi "https://doi.org/10.31219/osf.io/qkrdu" @default.
- W4379207863 hasPublicationYear "2023" @default.
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