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• W4379229554 abstract "The transforming growth factor-β (TGF-β) superfamily in insects regulated various physiological events, including immune response, growth and development, and metamorphosis. This complex network of signaling pathways involves conserved cell-surface receptors and signaling co-receptors that allow for precisely coordinated cellular events. However, the roles of TGF-β receptors, particularly the type II receptor Punt, in mediating the innate immunity in insects remains unclear. In this study, we used the red flour beetle, Tribolium castaneum, as a model species to investigate the role of TGF-β type II receptor Punt in mediating antimicrobial peptide (AMP) expression. Developmental and tissue-specific transcript profiles revealed Punt was constitutively expressed throughout development, with the highest transcript level in 1-day female pupae and the lowest transcript level in 18-day larvae. Tissue specific expression profiles showed the highest transcript level of Punt was observed in the Malpighian tubule and ovary in 18-day larvae and 1-day female adults, respectively, suggesting Punt might have distinct functions in larvae and adults. Further results indicated that Punt RNAi in the 18-day larvae led to increased transcript level of AMP genes through transcription factor Relish, leading to inhibition of Escherichia coli proliferation. Knockdown of Punt in larvae also led to splitting of adult elytra and abnormal compound eyes. Furthermore, knockdown of Punt during the female pupal stage resulted in increased transcript levels of AMP genes, as well as abnormal ovary, reduced fecundity, and failure of eggs to hatch. This study deepens our understanding of the biological significance of Punt in insect TGF-β signaling and lays the groundwork for further research of its role in insect immune response, development, and reproduction." @default.
• W4379229554 created "2023-06-04" @default.
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• W4379229554 date "2023-06-02" @default.
• W4379229554 modified "2023-09-27" @default.
• W4379229554 title "TGF-β Type II Receptor Punt Suppresses Antimicrobial Peptide Expression and Influences Development in Tribolium castaneum" @default.
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• W4379229554 doi "https://doi.org/10.3390/insects14060515" @default.
• W4379229554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37367331" @default.
• W4379229554 hasPublicationYear "2023" @default.
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