Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379230605> ?p ?o ?g. }
- W4379230605 endingPage "1316" @default.
- W4379230605 startingPage "1316" @default.
- W4379230605 abstract "The frequent SARS-CoV-2 variants have caused a continual challenge, weakening the effectiveness of current vaccines, and thus it is of great importance to induce robust and conserved T cellular immunity for developing the next-generation vaccine against SARS-CoV-2 variants. In this study, we proposed a conception of enhancing the SARS-CoV-2 specific T cell functionality by fusing autophagosome-associated LC3b protein to the nucleocapsid (N) (N-LC3b). When compared to N protein alone, the N-LC3b protein was more effectively targeted to the autophagosome/lysosome/MHC II compartment signal pathway and thus elicited stronger CD4+ and CD8+ T cell immune responses in mice. Importantly, the frequency of N-specific polyfunctional CD4+ and CD8+ T cells, which can simultaneously secrete multiple cytokines (IFN-γ+/IL-2+/TNF-α+), in the N-LC3b group was significantly higher than that in the N alone group. Moreover, there was a significantly improved T cell proliferation, especially for CD8+ T cells in the N-LC3b group. In addition, the N-LC3b also induced a robust humoral immune response, characterized by the Th1-biased IgG2a subclass antibodies against the SARS-CoV-2 N protein. Overall, these findings demonstrated that our strategy could effectively induce a potential SARS-CoV-2 specific T cellular immunity with enhanced magnitude, polyfunctionality, and proliferation, and thus provided insights to develop a promising strategy for the design of a novel universal vaccine against SARS-CoV-2 variants and other emerging infectious diseases." @default.
- W4379230605 created "2023-06-04" @default.
- W4379230605 creator A5004426269 @default.
- W4379230605 creator A5006190358 @default.
- W4379230605 creator A5039565419 @default.
- W4379230605 creator A5042636912 @default.
- W4379230605 creator A5066660351 @default.
- W4379230605 creator A5067307509 @default.
- W4379230605 creator A5073442077 @default.
- W4379230605 creator A5085995170 @default.
- W4379230605 date "2023-06-02" @default.
- W4379230605 modified "2023-10-11" @default.
- W4379230605 title "Enhancement of SARS-CoV-2 N Antigen-Specific T Cell Functionality by Modulating the Autophagy-Mediated Signal Pathway in Mice" @default.
- W4379230605 cites W1607996760 @default.
- W4379230605 cites W2007340000 @default.
- W4379230605 cites W2012505332 @default.
- W4379230605 cites W2025665129 @default.
- W4379230605 cites W2060472363 @default.
- W4379230605 cites W2074857405 @default.
- W4379230605 cites W2124712366 @default.
- W4379230605 cites W2143909711 @default.
- W4379230605 cites W2189790494 @default.
- W4379230605 cites W2325881814 @default.
- W4379230605 cites W2436938895 @default.
- W4379230605 cites W2602035017 @default.
- W4379230605 cites W2796061259 @default.
- W4379230605 cites W2915839491 @default.
- W4379230605 cites W3014721277 @default.
- W4379230605 cites W3023991776 @default.
- W4379230605 cites W3042183476 @default.
- W4379230605 cites W3048775784 @default.
- W4379230605 cites W3082438395 @default.
- W4379230605 cites W3095956988 @default.
- W4379230605 cites W3123175540 @default.
- W4379230605 cites W3131241993 @default.
- W4379230605 cites W3134324254 @default.
- W4379230605 cites W3151598068 @default.
- W4379230605 cites W3153636933 @default.
- W4379230605 cites W3158827494 @default.
- W4379230605 cites W3160683687 @default.
- W4379230605 cites W3168384292 @default.
- W4379230605 cites W3175747586 @default.
- W4379230605 cites W3177293754 @default.
- W4379230605 cites W4205331651 @default.
- W4379230605 cites W4207047906 @default.
- W4379230605 cites W4210493562 @default.
- W4379230605 cites W4221036889 @default.
- W4379230605 cites W4224268482 @default.
- W4379230605 cites W4225679003 @default.
- W4379230605 cites W4288886238 @default.
- W4379230605 cites W4312083102 @default.
- W4379230605 cites W4313252203 @default.
- W4379230605 cites W4320709194 @default.
- W4379230605 doi "https://doi.org/10.3390/v15061316" @default.
- W4379230605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37376617" @default.
- W4379230605 hasPublicationYear "2023" @default.
- W4379230605 type Work @default.
- W4379230605 citedByCount "2" @default.
- W4379230605 countsByYear W43792306052023 @default.
- W4379230605 crossrefType "journal-article" @default.
- W4379230605 hasAuthorship W4379230605A5004426269 @default.
- W4379230605 hasAuthorship W4379230605A5006190358 @default.
- W4379230605 hasAuthorship W4379230605A5039565419 @default.
- W4379230605 hasAuthorship W4379230605A5042636912 @default.
- W4379230605 hasAuthorship W4379230605A5066660351 @default.
- W4379230605 hasAuthorship W4379230605A5067307509 @default.
- W4379230605 hasAuthorship W4379230605A5073442077 @default.
- W4379230605 hasAuthorship W4379230605A5085995170 @default.
- W4379230605 hasBestOaLocation W43792306051 @default.
- W4379230605 hasConcept C147483822 @default.
- W4379230605 hasConcept C159047783 @default.
- W4379230605 hasConcept C159654299 @default.
- W4379230605 hasConcept C167672396 @default.
- W4379230605 hasConcept C190283241 @default.
- W4379230605 hasConcept C203014093 @default.
- W4379230605 hasConcept C203522944 @default.
- W4379230605 hasConcept C2776090121 @default.
- W4379230605 hasConcept C2779341262 @default.
- W4379230605 hasConcept C55493867 @default.
- W4379230605 hasConcept C86803240 @default.
- W4379230605 hasConcept C8891405 @default.
- W4379230605 hasConcept C95444343 @default.
- W4379230605 hasConceptScore W4379230605C147483822 @default.
- W4379230605 hasConceptScore W4379230605C159047783 @default.
- W4379230605 hasConceptScore W4379230605C159654299 @default.
- W4379230605 hasConceptScore W4379230605C167672396 @default.
- W4379230605 hasConceptScore W4379230605C190283241 @default.
- W4379230605 hasConceptScore W4379230605C203014093 @default.
- W4379230605 hasConceptScore W4379230605C203522944 @default.
- W4379230605 hasConceptScore W4379230605C2776090121 @default.
- W4379230605 hasConceptScore W4379230605C2779341262 @default.
- W4379230605 hasConceptScore W4379230605C55493867 @default.
- W4379230605 hasConceptScore W4379230605C86803240 @default.
- W4379230605 hasConceptScore W4379230605C8891405 @default.
- W4379230605 hasConceptScore W4379230605C95444343 @default.
- W4379230605 hasIssue "6" @default.
- W4379230605 hasLocation W43792306051 @default.
- W4379230605 hasLocation W43792306052 @default.