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- W4379231716 endingPage "575" @default.
- W4379231716 startingPage "575" @default.
- W4379231716 abstract "Photoreceptor membranes have a unique lipid composition. They contain a high level of polyunsaturated fatty acids including the most unsaturated fatty acid in nature, docosahexaenoic acid (22:6), and are enriched in phosphatidylethanolamines. The phospholipid composition and cholesterol content of the subcellular components of photoreceptor outer segments enables to divide photoreceptor membranes into three types: plasma membranes, young disc membranes, and old disc membranes. A high degree of lipid unsaturation, extended exposure to intensive irradiation, and high respiratory demands make these membranes sensitive to oxidative stress and lipid peroxidation. Moreover, all-trans retinal (AtRAL), which is a photoreactive product of visual pigment bleaching, accumulates transiently inside these membranes, where its concentration may reach a phototoxic level. An elevated concentration of AtRAL leads to accelerated formation and accumulation of bisretinoid condensation products such as A2E or AtRAL dimers. However, a possible structural impact of these retinoids on the photoreceptor-membrane properties has not yet been studied. In this work we focused just on this aspect. The changes induced by retinoids, although noticeable, seem not to be significant enough to be physiologically relevant. This is, however, an positive conclusion because it can be assumed that accumulation of AtRAL in photoreceptor membranes will not affect the transduction of visual signals and will not disturb the interaction of proteins engaged in this process." @default.
- W4379231716 created "2023-06-04" @default.
- W4379231716 creator A5009103441 @default.
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- W4379231716 creator A5092080427 @default.
- W4379231716 creator A5092080428 @default.
- W4379231716 creator A5092080429 @default.
- W4379231716 date "2023-06-01" @default.
- W4379231716 modified "2023-09-30" @default.
- W4379231716 title "Structural Impact of Selected Retinoids on Model Photoreceptor Membranes" @default.
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