FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379233114> ?p ?o ?g. }

• W4379233114 abstract "Background: Cancer-associated fibroblasts (CAFs) of ovarian cancer (OvC) are the most prevalent element of the tumor microenvironment (TM). By promoting angiogenesis, immunological suppression, and invasion, CAFs speed up the growth of tumors by changing the extracellular matrix’s structure and composition and/or initiating the epithelial cells (EPT). IL-33/ST2 signaling has drawn a lot of attention since it acts as a pro-tumor alarmin and encourages spread by altering TM. Methods: Differentially expressed genes (DEGs) of the OvC tumor microenvironment were found in the GEO database, qRT-PCR, western blotting, and immunohistochemistry, and their presence and changes in healthy and tumor tissue content were examined. Primary cultures of healthy fibroblasts and CAFs obtained from healthy and tumor tissues retrieved from OvC samples were used for in vitro and in vivo investigations. Cultured primary human CAFs were utilized to investigate the regulation and the IL-33/ST2 axis role in the inflammation reactions. Results: Although ST2 and IL-33 expression was detected in both epithelial (EPT) and fibroblast cells of ovarian cancer, they are more abundant in CAFs. Lipopolysaccharides, serum amyloid A1, and IL-1β, the inflammatory mediators, could all induce IL-33 expression through NF-κB activation in human CAFs. In turn, via the ST2 receptor, IL-33 affected the production of IL-6, IL-1β, and PTGS2 in human CAFs via the MAPKs-NF-κB pathway. Conclusion: Our findings suggest that IL-33/ST2 is affected by the interaction of CAFs and epithelial cells inside the tumor microenvironment. Activation of this axis leads to increased expression of inflammatory factors in tumor CAFs and EPT cells. Therefore, targeting the IL-33/ST2 axis could have potential value in the prevention of OvC progression." @default.
• W4379233114 created "2023-06-04" @default.
• W4379233114 creator A5000762852 @default.
• W4379233114 creator A5002150256 @default.
• W4379233114 creator A5018389767 @default.
• W4379233114 creator A5026302953 @default.
• W4379233114 creator A5031623183 @default.
• W4379233114 creator A5035045303 @default.
• W4379233114 creator A5038321193 @default.
• W4379233114 creator A5039088468 @default.
• W4379233114 creator A5063694655 @default.
• W4379233114 creator A5073838234 @default.
• W4379233114 creator A5075584187 @default.
• W4379233114 creator A5082927666 @default.
• W4379233114 creator A5092080808 @default.
• W4379233114 date "2023-06-02" @default.
• W4379233114 modified "2023-10-03" @default.
• W4379233114 title "Identification of novel candidate targets for suppressing ovarian cancer progression through IL-33/ST2 axis components using the system biology approach" @default.
• W4379233114 cites W1448114976 @default.
• W4379233114 cites W1527215597 @default.
• W4379233114 cites W1709510321 @default.
• W4379233114 cites W1876452769 @default.
• W4379233114 cites W1928503725 @default.
• W4379233114 cites W1936845913 @default.
• W4379233114 cites W1968955229 @default.
• W4379233114 cites W1974567018 @default.
• W4379233114 cites W1980926721 @default.
• W4379233114 cites W1985987855 @default.
• W4379233114 cites W1986662234 @default.
• W4379233114 cites W1992777534 @default.
• W4379233114 cites W1993814619 @default.
• W4379233114 cites W1993875664 @default.
• W4379233114 cites W2017448826 @default.
• W4379233114 cites W2036606290 @default.
• W4379233114 cites W2089956125 @default.
• W4379233114 cites W2102278945 @default.
• W4379233114 cites W2103912979 @default.
• W4379233114 cites W2104906501 @default.
• W4379233114 cites W2107060225 @default.
• W4379233114 cites W2113586126 @default.
• W4379233114 cites W2114843025 @default.
• W4379233114 cites W2115344071 @default.
• W4379233114 cites W2115954319 @default.
• W4379233114 cites W2126882378 @default.
• W4379233114 cites W2136850043 @default.
• W4379233114 cites W2161271012 @default.
• W4379233114 cites W2164664027 @default.
• W4379233114 cites W2165261531 @default.
• W4379233114 cites W2166623795 @default.
• W4379233114 cites W2169353806 @default.
• W4379233114 cites W2169589032 @default.
• W4379233114 cites W2216860662 @default.
• W4379233114 cites W2515338440 @default.
• W4379233114 cites W2533508881 @default.
• W4379233114 cites W2581065975 @default.
• W4379233114 cites W2598111292 @default.
• W4379233114 cites W2600132724 @default.
• W4379233114 cites W2609744794 @default.
• W4379233114 cites W2735527928 @default.
• W4379233114 cites W2765224588 @default.
• W4379233114 cites W2765357646 @default.
• W4379233114 cites W2771136649 @default.
• W4379233114 cites W2774776290 @default.
• W4379233114 cites W2779261498 @default.
• W4379233114 cites W2781525129 @default.
• W4379233114 cites W2783651671 @default.
• W4379233114 cites W2785608148 @default.
• W4379233114 cites W2785803176 @default.
• W4379233114 cites W2790044650 @default.
• W4379233114 cites W2790679007 @default.
• W4379233114 cites W2795993993 @default.
• W4379233114 cites W2800801906 @default.
• W4379233114 cites W2802071168 @default.
• W4379233114 cites W2808032469 @default.
• W4379233114 cites W2886498337 @default.
• W4379233114 cites W2888895595 @default.
• W4379233114 cites W2890938707 @default.
• W4379233114 cites W2898207129 @default.
• W4379233114 cites W2899057363 @default.
• W4379233114 cites W2904248238 @default.
• W4379233114 cites W2905872107 @default.
• W4379233114 cites W2911579280 @default.
• W4379233114 cites W2912410416 @default.
• W4379233114 cites W2934055254 @default.
• W4379233114 cites W3024803372 @default.
• W4379233114 cites W3112393471 @default.
• W4379233114 cites W3136443308 @default.
• W4379233114 cites W3164303435 @default.
• W4379233114 cites W3170776061 @default.
• W4379233114 cites W4220823996 @default.
• W4379233114 cites W4280509436 @default.
• W4379233114 cites W4280519098 @default.
• W4379233114 cites W4281476333 @default.
• W4379233114 cites W4290188763 @default.
• W4379233114 cites W4310493943 @default.
• W4379233114 cites W4311437317 @default.
• W4379233114 doi "https://doi.org/10.3389/fmolb.2023.1189527" @default.
• W4379233114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37333018" @default.
• W4379233114 hasPublicationYear "2023" @default.
• W4379233114 type Work @default.

• next