Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379282983> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4379282983 endingPage "e16528" @default.
- W4379282983 startingPage "e16528" @default.
- W4379282983 abstract "e16528 Background: Immune checkpoint inhibitors (ICI) have been shown to improve overall survival (OS) in patients with metastatic renal cell carcinoma (RCC) as compared to previous therapy with multi-kinase inhibitors (MKI). However, little is known about the effects of these drugs on male reproductive capacity and the current data regarding effects of MKI and ICI therapies on gonadal function and fertility are both limited and conflicting. We sought to evaluate effects of MKI and ICI on male reproductive function in patients with RCC. Methods: Male patients with RCC receiving MKI or ICI for a period of at least 3 months were identified. Inclusion criteria included age ≤ 50 years, no prior history of chemotherapy, and no prior history of medical or surgical conditions that would affect spermatogenesis such as hypogonadism, Klinefelter syndrome, or vasectomies. Patients were instructed to abstain from ejaculation 2 to 7 days prior to study collection. Follicle-stimulating hormone (FSH), luteinizing hormone (LH), morning testosterone, and a semen analysis was obtained for each patient and analyzed. Results: Of 10 patients, 5 (50%) were on ICI and 5 (50%) were on MKI. Of the patients on ICI, 2 (40%) exhibited abnormal semen morphology, motility, and sperm concentration. Of the patients on ICI, one exhibited elevated LH and FSH levels and one exhibited elevated LH levels only. Of the patients on MKI, 2 (40%) exhibited abnormal semen morphology, motility, and sperm concentration. One patient on MKI exhibited elevated LH and FSH levels. All patients had normal testosterone levels. Conclusions: Our preliminary descriptive data analysis suggests that both ICI and MKI may affect semen morphology and motility, sperm concentration, and LH and FSH levels, but does not affect testosterone levels. Due to the currently limited sample size, abnormal semen analysis and hormone levels may be attributable to confounding factors, such as performance status, the metastatic disease itself, comorbidities, etc. Study recruitment and analysis are ongoing." @default.
- W4379282983 created "2023-06-05" @default.
- W4379282983 creator A5003711333 @default.
- W4379282983 creator A5017054827 @default.
- W4379282983 creator A5037348260 @default.
- W4379282983 creator A5048701456 @default.
- W4379282983 creator A5058811400 @default.
- W4379282983 creator A5070699834 @default.
- W4379282983 creator A5071324969 @default.
- W4379282983 creator A5090807122 @default.
- W4379282983 creator A5091808227 @default.
- W4379282983 date "2023-06-01" @default.
- W4379282983 modified "2023-09-25" @default.
- W4379282983 title "Immune checkpoint inhibitor effects on male reproduction." @default.
- W4379282983 doi "https://doi.org/10.1200/jco.2023.41.16_suppl.e16528" @default.
- W4379282983 hasPublicationYear "2023" @default.
- W4379282983 type Work @default.
- W4379282983 citedByCount "0" @default.
- W4379282983 crossrefType "journal-article" @default.
- W4379282983 hasAuthorship W4379282983A5003711333 @default.
- W4379282983 hasAuthorship W4379282983A5017054827 @default.
- W4379282983 hasAuthorship W4379282983A5037348260 @default.
- W4379282983 hasAuthorship W4379282983A5048701456 @default.
- W4379282983 hasAuthorship W4379282983A5058811400 @default.
- W4379282983 hasAuthorship W4379282983A5070699834 @default.
- W4379282983 hasAuthorship W4379282983A5071324969 @default.
- W4379282983 hasAuthorship W4379282983A5090807122 @default.
- W4379282983 hasAuthorship W4379282983A5091808227 @default.
- W4379282983 hasConcept C123765429 @default.
- W4379282983 hasConcept C126322002 @default.
- W4379282983 hasConcept C126894567 @default.
- W4379282983 hasConcept C134018914 @default.
- W4379282983 hasConcept C143998085 @default.
- W4379282983 hasConcept C16685009 @default.
- W4379282983 hasConcept C2777420699 @default.
- W4379282983 hasConcept C2777589648 @default.
- W4379282983 hasConcept C2777688143 @default.
- W4379282983 hasConcept C2778575703 @default.
- W4379282983 hasConcept C2779234561 @default.
- W4379282983 hasConcept C2779279165 @default.
- W4379282983 hasConcept C2779279991 @default.
- W4379282983 hasConcept C2781087480 @default.
- W4379282983 hasConcept C54355233 @default.
- W4379282983 hasConcept C71315377 @default.
- W4379282983 hasConcept C71924100 @default.
- W4379282983 hasConcept C86803240 @default.
- W4379282983 hasConceptScore W4379282983C123765429 @default.
- W4379282983 hasConceptScore W4379282983C126322002 @default.
- W4379282983 hasConceptScore W4379282983C126894567 @default.
- W4379282983 hasConceptScore W4379282983C134018914 @default.
- W4379282983 hasConceptScore W4379282983C143998085 @default.
- W4379282983 hasConceptScore W4379282983C16685009 @default.
- W4379282983 hasConceptScore W4379282983C2777420699 @default.
- W4379282983 hasConceptScore W4379282983C2777589648 @default.
- W4379282983 hasConceptScore W4379282983C2777688143 @default.
- W4379282983 hasConceptScore W4379282983C2778575703 @default.
- W4379282983 hasConceptScore W4379282983C2779234561 @default.
- W4379282983 hasConceptScore W4379282983C2779279165 @default.
- W4379282983 hasConceptScore W4379282983C2779279991 @default.
- W4379282983 hasConceptScore W4379282983C2781087480 @default.
- W4379282983 hasConceptScore W4379282983C54355233 @default.
- W4379282983 hasConceptScore W4379282983C71315377 @default.
- W4379282983 hasConceptScore W4379282983C71924100 @default.
- W4379282983 hasConceptScore W4379282983C86803240 @default.
- W4379282983 hasIssue "16_suppl" @default.
- W4379282983 hasLocation W43792829831 @default.
- W4379282983 hasOpenAccess W4379282983 @default.
- W4379282983 hasPrimaryLocation W43792829831 @default.
- W4379282983 hasRelatedWork W1988486434 @default.
- W4379282983 hasRelatedWork W1991634850 @default.
- W4379282983 hasRelatedWork W2025304600 @default.
- W4379282983 hasRelatedWork W2052998204 @default.
- W4379282983 hasRelatedWork W2064034534 @default.
- W4379282983 hasRelatedWork W2073502422 @default.
- W4379282983 hasRelatedWork W2790556289 @default.
- W4379282983 hasRelatedWork W3021050921 @default.
- W4379282983 hasRelatedWork W4313044697 @default.
- W4379282983 hasRelatedWork W2411910748 @default.
- W4379282983 hasVolume "41" @default.
- W4379282983 isParatext "false" @default.
- W4379282983 isRetracted "false" @default.
- W4379282983 workType "article" @default.