Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379285767> ?p ?o ?g. }
- W4379285767 endingPage "105616" @default.
- W4379285767 startingPage "105616" @default.
- W4379285767 abstract "Cellulose nanocrystals (CNCs) display remarkable strength and physicochemical properties with significant potential applications. To better understand the potential adjuvanticity of a nanomaterial, it is important to investigate the extent of the immunological response, the mechanisms by which they elicit this response, and how this response is associated with their physicochemical characteristics. In this study, we investigated the potential mechanisms of immunomodulation and redox activity of two chemically related cationic CNC derivatives (CNC-METAC-1B and CNC-METAC-2B), using human peripheral blood mononuclear cells and mouse macrophage cells (J774A.1). Our data demonstrated that the biological effects caused by these nanomaterials occurred mainly with short term exposure. We observed opposite immunomodulatory activity between the tested nanomaterials. CNC-METAC-2B, induced IL-1β secretion at 2 h while CNC-METAC-1B decreased it at 24 h of treatment. In addition, both nanomaterials caused more noticeable increases in mitochondrial reactive oxygen species (ROS) at early time. The differences in apparent sizes of the two cationic nanomaterials could explain, at least in part, the discrepancies in biological effects, despite their closely related surface charges. This work provides initial insights about the complexity of the in vitro mechanism of action of these nanomaterials as well as foundation knowledge for the development of cationic CNCs as potential immunomodulators." @default.
- W4379285767 created "2023-06-05" @default.
- W4379285767 creator A5007893657 @default.
- W4379285767 creator A5040781983 @default.
- W4379285767 creator A5060273434 @default.
- W4379285767 creator A5068254190 @default.
- W4379285767 creator A5070237830 @default.
- W4379285767 creator A5080425099 @default.
- W4379285767 creator A5085013677 @default.
- W4379285767 date "2023-09-01" @default.
- W4379285767 modified "2023-09-27" @default.
- W4379285767 title "In vitro immune and redox response induced by cationic cellulose-based nanomaterials" @default.
- W4379285767 cites W126188432 @default.
- W4379285767 cites W1982041674 @default.
- W4379285767 cites W1997572777 @default.
- W4379285767 cites W1999620455 @default.
- W4379285767 cites W2024212563 @default.
- W4379285767 cites W2045914675 @default.
- W4379285767 cites W2046899428 @default.
- W4379285767 cites W2073446096 @default.
- W4379285767 cites W2076113630 @default.
- W4379285767 cites W2076195979 @default.
- W4379285767 cites W2078944426 @default.
- W4379285767 cites W2091218781 @default.
- W4379285767 cites W2109520483 @default.
- W4379285767 cites W2118918019 @default.
- W4379285767 cites W2122287804 @default.
- W4379285767 cites W2123926349 @default.
- W4379285767 cites W2137319196 @default.
- W4379285767 cites W2146994220 @default.
- W4379285767 cites W2150558166 @default.
- W4379285767 cites W2167534105 @default.
- W4379285767 cites W2330559036 @default.
- W4379285767 cites W2416965075 @default.
- W4379285767 cites W2527713000 @default.
- W4379285767 cites W2606968610 @default.
- W4379285767 cites W2727738717 @default.
- W4379285767 cites W2759201686 @default.
- W4379285767 cites W2759626433 @default.
- W4379285767 cites W2766228398 @default.
- W4379285767 cites W2769622412 @default.
- W4379285767 cites W2775755403 @default.
- W4379285767 cites W2829197377 @default.
- W4379285767 cites W2899293571 @default.
- W4379285767 cites W2900063234 @default.
- W4379285767 cites W2908302391 @default.
- W4379285767 cites W2941157893 @default.
- W4379285767 cites W2954782052 @default.
- W4379285767 cites W2971239446 @default.
- W4379285767 cites W3003334896 @default.
- W4379285767 cites W3009916283 @default.
- W4379285767 cites W3045537494 @default.
- W4379285767 cites W3049542108 @default.
- W4379285767 cites W3110393011 @default.
- W4379285767 doi "https://doi.org/10.1016/j.tiv.2023.105616" @default.
- W4379285767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37279824" @default.
- W4379285767 hasPublicationYear "2023" @default.
- W4379285767 type Work @default.
- W4379285767 citedByCount "0" @default.
- W4379285767 crossrefType "journal-article" @default.
- W4379285767 hasAuthorship W4379285767A5007893657 @default.
- W4379285767 hasAuthorship W4379285767A5040781983 @default.
- W4379285767 hasAuthorship W4379285767A5060273434 @default.
- W4379285767 hasAuthorship W4379285767A5068254190 @default.
- W4379285767 hasAuthorship W4379285767A5070237830 @default.
- W4379285767 hasAuthorship W4379285767A5080425099 @default.
- W4379285767 hasAuthorship W4379285767A5085013677 @default.
- W4379285767 hasConcept C12554922 @default.
- W4379285767 hasConcept C127445965 @default.
- W4379285767 hasConcept C138631740 @default.
- W4379285767 hasConcept C155672457 @default.
- W4379285767 hasConcept C171250308 @default.
- W4379285767 hasConcept C178790620 @default.
- W4379285767 hasConcept C183882617 @default.
- W4379285767 hasConcept C185592680 @default.
- W4379285767 hasConcept C192562407 @default.
- W4379285767 hasConcept C202751555 @default.
- W4379285767 hasConcept C203014093 @default.
- W4379285767 hasConcept C48349386 @default.
- W4379285767 hasConcept C55493867 @default.
- W4379285767 hasConcept C86803240 @default.
- W4379285767 hasConcept C8891405 @default.
- W4379285767 hasConceptScore W4379285767C12554922 @default.
- W4379285767 hasConceptScore W4379285767C127445965 @default.
- W4379285767 hasConceptScore W4379285767C138631740 @default.
- W4379285767 hasConceptScore W4379285767C155672457 @default.
- W4379285767 hasConceptScore W4379285767C171250308 @default.
- W4379285767 hasConceptScore W4379285767C178790620 @default.
- W4379285767 hasConceptScore W4379285767C183882617 @default.
- W4379285767 hasConceptScore W4379285767C185592680 @default.
- W4379285767 hasConceptScore W4379285767C192562407 @default.
- W4379285767 hasConceptScore W4379285767C202751555 @default.
- W4379285767 hasConceptScore W4379285767C203014093 @default.
- W4379285767 hasConceptScore W4379285767C48349386 @default.
- W4379285767 hasConceptScore W4379285767C55493867 @default.
- W4379285767 hasConceptScore W4379285767C86803240 @default.
- W4379285767 hasConceptScore W4379285767C8891405 @default.
- W4379285767 hasFunder F4320306076 @default.