Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379356186> ?p ?o ?g. }
- W4379356186 endingPage "104615" @default.
- W4379356186 startingPage "104615" @default.
- W4379356186 abstract "Doxorubicin (DOX) induces cardiotoxicity, hepatotoxicity and nephrotoxicity, through multiplicity of mechanisms involving the production of free radicals causing oxidative stress and apoptosis. Zinc oxide (ZnO) nanomaterials, besides biocompatibility and biodegradability, also show the protective effect on cells and organs. The current study aspires to delve into the protective effects of ZnO in DOX-loaded ZnO nanoflowers (DOX-ZnO-NFs). Comparative in-vitro toxicities of DOX, blank zinc oxide nanoflowers (ZnO-NFs) and DOX-ZnO-NFs were examined against in-vitro normal Henrietta Lacks (HeLa) cell line and in-vivo in the Wistar rats. The change in body weight, hematological parameters and biochemical biomarkers of heart, kidney and liver and histopathology of tissues were examined at 24 h and after 14 days post dosing of the test moieties. DOX-ZnO-NFs portrayed biocompatibility and safety in the HeLa cells and the kidneys, liver and heart of Wistar rats. At 30 μg/ml, DOX-ZnO-NFs showed 72.53 ± 0.39% cell survival rate, relative to 80.59 ± 0.99% by ZnO-NFs and 13.8 ± 0.22%, by DOX. DOX-ZnO-NFs and ZnO-NFs caused slight change in organ's weight, minimum haemolysis, little effect on liver and kidney enzymes, improved activity of antioxidant enzymes and maintained tissues' architecture relative to the bare DOX. The drug-free ZnO-NFs with the maximum safety supported the protective effect of ZnO and, thus DOX-ZnO-NFs surmounted the DOX-induced systemic toxicity." @default.
- W4379356186 created "2023-06-05" @default.
- W4379356186 creator A5001083372 @default.
- W4379356186 creator A5008776062 @default.
- W4379356186 creator A5023056186 @default.
- W4379356186 creator A5041693180 @default.
- W4379356186 creator A5055489849 @default.
- W4379356186 creator A5073711042 @default.
- W4379356186 creator A5080799046 @default.
- W4379356186 creator A5092086091 @default.
- W4379356186 date "2023-08-01" @default.
- W4379356186 modified "2023-09-25" @default.
- W4379356186 title "Doxorubicin loaded zinc oxide nanoflowers – Surmounting drug-induced toxicity" @default.
- W4379356186 cites W1491504245 @default.
- W4379356186 cites W1520715706 @default.
- W4379356186 cites W1578802177 @default.
- W4379356186 cites W1591504141 @default.
- W4379356186 cites W1968351069 @default.
- W4379356186 cites W1993950777 @default.
- W4379356186 cites W2007713641 @default.
- W4379356186 cites W20305632 @default.
- W4379356186 cites W2030919960 @default.
- W4379356186 cites W2047409618 @default.
- W4379356186 cites W2056842005 @default.
- W4379356186 cites W2078178868 @default.
- W4379356186 cites W2078337753 @default.
- W4379356186 cites W2081482599 @default.
- W4379356186 cites W2086137262 @default.
- W4379356186 cites W2104424901 @default.
- W4379356186 cites W2106327590 @default.
- W4379356186 cites W2108004812 @default.
- W4379356186 cites W2130318636 @default.
- W4379356186 cites W2152337070 @default.
- W4379356186 cites W2152868870 @default.
- W4379356186 cites W2156573515 @default.
- W4379356186 cites W2267280165 @default.
- W4379356186 cites W2337457656 @default.
- W4379356186 cites W2565156559 @default.
- W4379356186 cites W2598259733 @default.
- W4379356186 cites W2755778068 @default.
- W4379356186 cites W2757887000 @default.
- W4379356186 cites W2766261199 @default.
- W4379356186 cites W2775590890 @default.
- W4379356186 cites W2777848148 @default.
- W4379356186 cites W2781753442 @default.
- W4379356186 cites W2792308604 @default.
- W4379356186 cites W2886310673 @default.
- W4379356186 cites W2904160357 @default.
- W4379356186 cites W2909489 @default.
- W4379356186 cites W2949625511 @default.
- W4379356186 cites W2979747836 @default.
- W4379356186 cites W2994922477 @default.
- W4379356186 cites W3013419261 @default.
- W4379356186 cites W3016876865 @default.
- W4379356186 cites W3029528140 @default.
- W4379356186 cites W3041514142 @default.
- W4379356186 cites W3048535760 @default.
- W4379356186 cites W3082338763 @default.
- W4379356186 cites W3090576699 @default.
- W4379356186 cites W3091157062 @default.
- W4379356186 cites W3096498410 @default.
- W4379356186 cites W3118593096 @default.
- W4379356186 cites W3122233670 @default.
- W4379356186 cites W3129933114 @default.
- W4379356186 cites W3154426821 @default.
- W4379356186 cites W3163249577 @default.
- W4379356186 cites W3167466362 @default.
- W4379356186 cites W3171241006 @default.
- W4379356186 cites W3174377263 @default.
- W4379356186 cites W3175990970 @default.
- W4379356186 cites W3178074969 @default.
- W4379356186 cites W3187077226 @default.
- W4379356186 cites W3211940642 @default.
- W4379356186 cites W3216499135 @default.
- W4379356186 cites W4205679590 @default.
- W4379356186 cites W4206372730 @default.
- W4379356186 cites W4210553808 @default.
- W4379356186 cites W4223465030 @default.
- W4379356186 cites W4226396973 @default.
- W4379356186 cites W4238754411 @default.
- W4379356186 cites W4281392499 @default.
- W4379356186 cites W4281621455 @default.
- W4379356186 cites W4281679094 @default.
- W4379356186 cites W4283778974 @default.
- W4379356186 cites W4313561857 @default.
- W4379356186 doi "https://doi.org/10.1016/j.jddst.2023.104615" @default.
- W4379356186 hasPublicationYear "2023" @default.
- W4379356186 type Work @default.
- W4379356186 citedByCount "0" @default.
- W4379356186 crossrefType "journal-article" @default.
- W4379356186 hasAuthorship W4379356186A5001083372 @default.
- W4379356186 hasAuthorship W4379356186A5008776062 @default.
- W4379356186 hasAuthorship W4379356186A5023056186 @default.
- W4379356186 hasAuthorship W4379356186A5041693180 @default.
- W4379356186 hasAuthorship W4379356186A5055489849 @default.
- W4379356186 hasAuthorship W4379356186A5073711042 @default.
- W4379356186 hasAuthorship W4379356186A5080799046 @default.
- W4379356186 hasAuthorship W4379356186A5092086091 @default.