Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379371205> ?p ?o ?g. }
- W4379371205 endingPage "389" @default.
- W4379371205 startingPage "381" @default.
- W4379371205 abstract "Glial cell line-derived neurotrophic factor (GDNF) is a strong candidate agent in the neuroprotective treatment of Parkinson's disease (PD). We investigated whether adeno-associated viral (AAV) vector-mediated delivery of a GDNF gene in a delayed manner could prevent progressive degeneration of dopaminergic (DA) neurons, while preserving a functional nigrostriatal pathway. Four weeks after a unilateral intrastriatal injection of 6-hydroxydopamine (6-OHDA), rats received injection of AAV vectors expressing GDNF tagged with FLAG peptide (AAV-GDNFflag) or β-galactosidase (AAV-LacZ) into the lesioned striatum. Immunostaining for FLAG demonstrated retrograde transport of GDNFflag to the substantia nigra (SN). The density of tyrosine hydroxylase (TH)-positive DA fibers in the striatum and the number of TH-positive or cholera toxin subunit B (CTB, neuronal tracer)-labeled neurons in the SN were significantly greater in the AAV-GDNFflag group than in the AAV-LacZ group. Dopamine levels and those of its metabolites in the striatum were remarkably higher in the AAV-GDNFflag group compared with the control group. Consistent with anatomical and biochemical changes, significant behavioral recovery was observed from 4–20 weeks following AAV-GDNFflag injection. These data indicate that a delayed delivery of GDNF gene using AAV vector is efficacious even 4 weeks after the onset of progressive degeneration in a rat model of PD." @default.
- W4379371205 created "2023-06-06" @default.
- W4379371205 creator A5002986053 @default.
- W4379371205 creator A5004939550 @default.
- W4379371205 creator A5007531407 @default.
- W4379371205 creator A5011953072 @default.
- W4379371205 creator A5017641271 @default.
- W4379371205 creator A5017834677 @default.
- W4379371205 creator A5026636989 @default.
- W4379371205 creator A5041075459 @default.
- W4379371205 creator A5064919780 @default.
- W4379371205 creator A5065280384 @default.
- W4379371205 creator A5068426528 @default.
- W4379371205 creator A5072129118 @default.
- W4379371205 creator A5087113538 @default.
- W4379371205 creator A5089894315 @default.
- W4379371205 date "2002-03-01" @default.
- W4379371205 modified "2023-10-17" @default.
- W4379371205 title "Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease" @default.
- W4379371205 cites W1795898662 @default.
- W4379371205 cites W1970416276 @default.
- W4379371205 cites W1975637203 @default.
- W4379371205 cites W1986546861 @default.
- W4379371205 cites W1988463041 @default.
- W4379371205 cites W1988987018 @default.
- W4379371205 cites W1993629435 @default.
- W4379371205 cites W2004116738 @default.
- W4379371205 cites W2006513044 @default.
- W4379371205 cites W2007105697 @default.
- W4379371205 cites W2015516504 @default.
- W4379371205 cites W2016390889 @default.
- W4379371205 cites W2019019227 @default.
- W4379371205 cites W2026854040 @default.
- W4379371205 cites W2027094797 @default.
- W4379371205 cites W2028607742 @default.
- W4379371205 cites W2029098021 @default.
- W4379371205 cites W2030645047 @default.
- W4379371205 cites W2035381900 @default.
- W4379371205 cites W2038036971 @default.
- W4379371205 cites W2043458930 @default.
- W4379371205 cites W2044731567 @default.
- W4379371205 cites W2057159662 @default.
- W4379371205 cites W2057374599 @default.
- W4379371205 cites W2061219878 @default.
- W4379371205 cites W2065000444 @default.
- W4379371205 cites W2073539399 @default.
- W4379371205 cites W2075249157 @default.
- W4379371205 cites W2079935484 @default.
- W4379371205 cites W2086616170 @default.
- W4379371205 cites W2088827109 @default.
- W4379371205 cites W2092462980 @default.
- W4379371205 cites W2108724455 @default.
- W4379371205 cites W2139661803 @default.
- W4379371205 cites W2150857721 @default.
- W4379371205 cites W2151349288 @default.
- W4379371205 cites W2154452702 @default.
- W4379371205 cites W2159047344 @default.
- W4379371205 cites W2161634584 @default.
- W4379371205 cites W2177094286 @default.
- W4379371205 doi "https://doi.org/10.1038/sj.gt.3301682" @default.
- W4379371205 hasPublicationYear "2002" @default.
- W4379371205 type Work @default.
- W4379371205 citedByCount "76" @default.
- W4379371205 countsByYear W43793712052012 @default.
- W4379371205 countsByYear W43793712052013 @default.
- W4379371205 countsByYear W43793712052014 @default.
- W4379371205 countsByYear W43793712052015 @default.
- W4379371205 countsByYear W43793712052017 @default.
- W4379371205 countsByYear W43793712052018 @default.
- W4379371205 countsByYear W43793712052019 @default.
- W4379371205 countsByYear W43793712052020 @default.
- W4379371205 countsByYear W43793712052021 @default.
- W4379371205 countsByYear W43793712052022 @default.
- W4379371205 crossrefType "journal-article" @default.
- W4379371205 hasAuthorship W4379371205A5002986053 @default.
- W4379371205 hasAuthorship W4379371205A5004939550 @default.
- W4379371205 hasAuthorship W4379371205A5007531407 @default.
- W4379371205 hasAuthorship W4379371205A5011953072 @default.
- W4379371205 hasAuthorship W4379371205A5017641271 @default.
- W4379371205 hasAuthorship W4379371205A5017834677 @default.
- W4379371205 hasAuthorship W4379371205A5026636989 @default.
- W4379371205 hasAuthorship W4379371205A5041075459 @default.
- W4379371205 hasAuthorship W4379371205A5064919780 @default.
- W4379371205 hasAuthorship W4379371205A5065280384 @default.
- W4379371205 hasAuthorship W4379371205A5068426528 @default.
- W4379371205 hasAuthorship W4379371205A5072129118 @default.
- W4379371205 hasAuthorship W4379371205A5087113538 @default.
- W4379371205 hasAuthorship W4379371205A5089894315 @default.
- W4379371205 hasBestOaLocation W43793712051 @default.
- W4379371205 hasConcept C104317684 @default.
- W4379371205 hasConcept C111599444 @default.
- W4379371205 hasConcept C126322002 @default.
- W4379371205 hasConcept C134018914 @default.
- W4379371205 hasConcept C135983454 @default.
- W4379371205 hasConcept C137183658 @default.
- W4379371205 hasConcept C159167319 @default.
- W4379371205 hasConcept C160539049 @default.
- W4379371205 hasConcept C169760540 @default.