FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379376476> ?p ?o ?g. }

• W4379376476 endingPage "C242" @default.
• W4379376476 startingPage "C224" @default.
• W4379376476 abstract "Mitochondrial function is widely recognized as a major determinant of health, emphasizing the importance of understanding the mechanisms promoting mitochondrial quality in various tissues. Recently, the mitochondrial unfolded protein response (UPR mt ) has come into focus as a modulator of mitochondrial homeostasis, particularly in stress conditions. In muscle, the necessity for activating transcription factor 4 (ATF4) and its role in regulating mitochondrial quality control (MQC) have yet to be determined. We overexpressed (OE) and knocked down ATF4 in C2C12 myoblasts, differentiated them to myotubes for 5 days, and subjected them to acute (ACA) or chronic (CCA) contractile activity. ATF4 mediated myotube formation through the regulated expression of myogenic factors, mainly Myc and myoblast determination protein 1 (MyoD), and suppressed mitochondrial biogenesis basally through peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1α). However, our data also show that ATF4 expression levels are directly related to mitochondrial fusion and dynamics, UPR mt activation, as well as lysosomal biogenesis and autophagy. Thus, ATF4 promoted enhanced mitochondrial networking, protein handling, and the capacity for clearance of dysfunctional organelles under stress conditions, despite lower levels of mitophagy flux with OE. Indeed, we found that ATF4 promoted the formation of a smaller pool of high-functioning mitochondria that are more responsive to contractile activity and have higher oxygen consumption rates and lower reactive oxygen species levels. These data provide evidence that ATF4 is both necessary and sufficient for mitochondrial quality control and adaptation during both differentiation and contractile activity, thus advancing the current understanding of ATF4 beyond its canonical functions to include the regulation of mitochondrial morphology, lysosomal biogenesis, and mitophagy in muscle cells." @default.
• W4379376476 created "2023-06-06" @default.
• W4379376476 creator A5010639410 @default.
• W4379376476 creator A5065876747 @default.
• W4379376476 creator A5076563879 @default.
• W4379376476 date "2023-07-01" @default.
• W4379376476 modified "2023-10-12" @default.
• W4379376476 title "Activating transcription factor 4 regulates mitochondrial content, morphology, and function in differentiating skeletal muscle myotubes" @default.
• W4379376476 cites W1512819323 @default.
• W4379376476 cites W1813667843 @default.
• W4379376476 cites W1965629756 @default.
• W4379376476 cites W1968024017 @default.
• W4379376476 cites W1980438612 @default.
• W4379376476 cites W1988276481 @default.
• W4379376476 cites W2001566658 @default.
• W4379376476 cites W2008062030 @default.
• W4379376476 cites W2009272245 @default.
• W4379376476 cites W2017268286 @default.
• W4379376476 cites W2023470228 @default.
• W4379376476 cites W2026414725 @default.
• W4379376476 cites W2030567780 @default.
• W4379376476 cites W2032382748 @default.
• W4379376476 cites W2032861840 @default.
• W4379376476 cites W2033378839 @default.
• W4379376476 cites W2035081929 @default.
• W4379376476 cites W2042588061 @default.
• W4379376476 cites W2048098925 @default.
• W4379376476 cites W2076131270 @default.
• W4379376476 cites W2083014447 @default.
• W4379376476 cites W2085640002 @default.
• W4379376476 cites W2088224247 @default.
• W4379376476 cites W2095154745 @default.
• W4379376476 cites W2099377713 @default.
• W4379376476 cites W2103271167 @default.
• W4379376476 cites W2107945166 @default.
• W4379376476 cites W2108738634 @default.
• W4379376476 cites W2112195082 @default.
• W4379376476 cites W2115150337 @default.
• W4379376476 cites W2115742671 @default.
• W4379376476 cites W2126525177 @default.
• W4379376476 cites W2127848114 @default.
• W4379376476 cites W2131632095 @default.
• W4379376476 cites W2147459821 @default.
• W4379376476 cites W2153029275 @default.
• W4379376476 cites W2155881926 @default.
• W4379376476 cites W2158296218 @default.
• W4379376476 cites W2160466549 @default.
• W4379376476 cites W2169696860 @default.
• W4379376476 cites W2171183626 @default.
• W4379376476 cites W2171267283 @default.
• W4379376476 cites W2216710583 @default.
• W4379376476 cites W2265499708 @default.
• W4379376476 cites W2277318350 @default.
• W4379376476 cites W2279851289 @default.
• W4379376476 cites W2314998955 @default.
• W4379376476 cites W2332100992 @default.
• W4379376476 cites W2344859455 @default.
• W4379376476 cites W2461089329 @default.
• W4379376476 cites W2474050726 @default.
• W4379376476 cites W2518959324 @default.
• W4379376476 cites W2592094354 @default.
• W4379376476 cites W2605465471 @default.
• W4379376476 cites W2605910555 @default.
• W4379376476 cites W2606122737 @default.
• W4379376476 cites W2618870156 @default.
• W4379376476 cites W2620825787 @default.
• W4379376476 cites W2742971656 @default.
• W4379376476 cites W2748137738 @default.
• W4379376476 cites W2793897503 @default.
• W4379376476 cites W2803872607 @default.
• W4379376476 cites W2885921218 @default.
• W4379376476 cites W2886249166 @default.
• W4379376476 cites W2889742267 @default.
• W4379376476 cites W2890182482 @default.
• W4379376476 cites W2910040256 @default.
• W4379376476 cites W2948750686 @default.
• W4379376476 cites W2981577392 @default.
• W4379376476 cites W2985749257 @default.
• W4379376476 cites W3009495596 @default.
• W4379376476 cites W3016730471 @default.
• W4379376476 cites W3029529179 @default.
• W4379376476 cites W3034423638 @default.
• W4379376476 cites W3035848569 @default.
• W4379376476 cites W3098787407 @default.
• W4379376476 cites W3135675512 @default.
• W4379376476 cites W4200466215 @default.
• W4379376476 cites W4210518897 @default.
• W4379376476 cites W4223937132 @default.
• W4379376476 cites W4292674157 @default.
• W4379376476 cites W4362522512 @default.
• W4379376476 doi "https://doi.org/10.1152/ajpcell.00080.2023" @default.
• W4379376476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37273238" @default.
• W4379376476 hasPublicationYear "2023" @default.
• W4379376476 type Work @default.
• W4379376476 citedByCount "0" @default.
• W4379376476 crossrefType "journal-article" @default.
• W4379376476 hasAuthorship W4379376476A5010639410 @default.
• W4379376476 hasAuthorship W4379376476A5065876747 @default.

• next