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- W4379380506 startingPage "112282" @default.
- W4379380506 abstract "Heme proteins perform diverse biochemical functions using a single iron porphyrin cofactor. This versatility makes them attractive platforms for the development of new functional proteins. While directed evolution and metal substitution have expanded the properties, reactivity, and applications of heme proteins, the incorporation of porphyrin analogs remains an underexplored approach. This review discusses the replacement of heme with non-porphyrin cofactors, such as porphycene, corrole, tetradehydrocorrin, phthalocyanine, and salophen, and the attendant properties of these conjugates. While structurally similar, each ligand exhibits distinct optical and redox properties, as well as unique chemical reactivity. These hybrids serve as model systems to elucidate the effects of the protein environment on the electronic structure, redox potentials, optical properties, or other features of the porphyrin analog. Protein encapsulation can confer distinct chemical reactivity or selectivity of artificial metalloenzymes that cannot be achieved with the small molecule catalyst alone. Additionally, these conjugates can interfere with heme acquisition and uptake in pathogenic bacteria, providing an inroad to innovative antibiotic strategies. Together, these examples illustrate the diverse functionality that can be achieved by cofactor substitution. The further expansion of this approach will access unexplored chemical space, enabling the development of superior catalysts and the creation of heme proteins with emergent properties." @default.
- W4379380506 created "2023-06-06" @default.
- W4379380506 creator A5030907430 @default.
- W4379380506 date "2023-09-01" @default.
- W4379380506 modified "2023-09-23" @default.
- W4379380506 title "Diversifying the functions of heme proteins with non-porphyrin cofactors" @default.
- W4379380506 cites W1434381939 @default.
- W4379380506 cites W1562699433 @default.
- W4379380506 cites W1764465661 @default.
- W4379380506 cites W1839404318 @default.
- W4379380506 cites W1965361505 @default.
- W4379380506 cites W1965745086 @default.
- W4379380506 cites W1970101156 @default.
- W4379380506 cites W1971263597 @default.
- W4379380506 cites W1972190772 @default.
- W4379380506 cites W1976179584 @default.
- W4379380506 cites W1980419942 @default.
- W4379380506 cites W1982155086 @default.
- W4379380506 cites W1984548430 @default.
- W4379380506 cites W1988059127 @default.
- W4379380506 cites W1990095828 @default.
- W4379380506 cites W1991861960 @default.
- W4379380506 cites W1993293174 @default.
- W4379380506 cites W1996610300 @default.
- W4379380506 cites W1999326244 @default.
- W4379380506 cites W1999616324 @default.
- W4379380506 cites W1999927339 @default.
- W4379380506 cites W2002895227 @default.
- W4379380506 cites W2003484874 @default.
- W4379380506 cites W2004075830 @default.
- W4379380506 cites W2005441809 @default.
- W4379380506 cites W2007471212 @default.
- W4379380506 cites W2008080366 @default.
- W4379380506 cites W2008209363 @default.
- W4379380506 cites W2009508860 @default.
- W4379380506 cites W2009541344 @default.
- W4379380506 cites W2012714287 @default.
- W4379380506 cites W2012715667 @default.
- W4379380506 cites W2013064733 @default.
- W4379380506 cites W2016122877 @default.
- W4379380506 cites W2016286328 @default.
- W4379380506 cites W2016386474 @default.
- W4379380506 cites W2017059042 @default.
- W4379380506 cites W2018132271 @default.
- W4379380506 cites W2019137326 @default.
- W4379380506 cites W2022431155 @default.
- W4379380506 cites W2024575202 @default.
- W4379380506 cites W2030015414 @default.
- W4379380506 cites W2031326615 @default.
- W4379380506 cites W2031377644 @default.
- W4379380506 cites W2037178507 @default.
- W4379380506 cites W2039056303 @default.
- W4379380506 cites W2039910356 @default.
- W4379380506 cites W2041615721 @default.
- W4379380506 cites W2042728588 @default.
- W4379380506 cites W2044399689 @default.
- W4379380506 cites W2045399650 @default.
- W4379380506 cites W2046423488 @default.
- W4379380506 cites W2049747650 @default.
- W4379380506 cites W2050149237 @default.
- W4379380506 cites W2051734899 @default.
- W4379380506 cites W2059108388 @default.
- W4379380506 cites W2068054841 @default.
- W4379380506 cites W2068431821 @default.
- W4379380506 cites W2073275267 @default.
- W4379380506 cites W2074907938 @default.
- W4379380506 cites W2075381111 @default.
- W4379380506 cites W2079054296 @default.
- W4379380506 cites W2087002393 @default.
- W4379380506 cites W2087019108 @default.
- W4379380506 cites W2087714810 @default.
- W4379380506 cites W2088219665 @default.
- W4379380506 cites W2094130145 @default.
- W4379380506 cites W2095091055 @default.
- W4379380506 cites W2095722652 @default.
- W4379380506 cites W2096214645 @default.
- W4379380506 cites W2099282718 @default.
- W4379380506 cites W2104606033 @default.
- W4379380506 cites W2109840355 @default.
- W4379380506 cites W2114475207 @default.
- W4379380506 cites W2123555047 @default.
- W4379380506 cites W2127027843 @default.
- W4379380506 cites W2133646233 @default.
- W4379380506 cites W2146486446 @default.
- W4379380506 cites W2149330840 @default.
- W4379380506 cites W2150829534 @default.
- W4379380506 cites W2162833635 @default.
- W4379380506 cites W2165547557 @default.
- W4379380506 cites W2185747041 @default.
- W4379380506 cites W2226641798 @default.
- W4379380506 cites W2236592009 @default.
- W4379380506 cites W2295559222 @default.
- W4379380506 cites W2317684707 @default.
- W4379380506 cites W2317873538 @default.
- W4379380506 cites W2327734484 @default.
- W4379380506 cites W2327822476 @default.
- W4379380506 cites W2335267576 @default.
- W4379380506 cites W2389622235 @default.