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- W4379380640 abstract "A 33-year-old kidney transplant (KT) recipient presented with a disseminated pruritic, painful, vesicular rash and hepatitis three weeks after receiving a varicella vaccine (VAR). A skin lesion biopsy sent to the Centers for Disease Control and Prevention (CDC) for genotyping confirmed vaccine-strain varicella-zoster virus (VZV) (Oka strain; vOka). The patient was successfully treated with intravenous acyclovir during a prolonged hospital stay. This case supports the contraindication of VAR in adult KT recipients and highlights the potential for severe illness when used in this population. Optimally, VZV-seronegative KT candidates should receive VAR before starting immunosuppressive medications. If this opportunity is missed, the recombinant varicella-zoster vaccine (RZV) might be considered following transplantation as it is already recommended to prevent herpes zoster in VZV-seropositive immunocompromised adults. Further study is needed as data are limited on the safety and efficacy of RZV in VZV-seronegative immunocompromised adults for primary varicella prevention." @default.
- W4379380640 created "2023-06-06" @default.
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- W4379380640 date "2023-06-01" @default.
- W4379380640 modified "2023-10-12" @default.
- W4379380640 title "Disseminated vaccine-induced varicella infection in a kidney transplant recipient" @default.
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- W4379380640 doi "https://doi.org/10.1016/j.ajt.2023.05.034" @default.
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