Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379383037> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4379383037 abstract "Significance: Dihydrolipoamide dehydrogenase (DLDH) is a flavin-dependent disulfide oxidoreductase. The active form of DLDH is a stable homodimer and its deficiencies have been linked to numerous metabolic disorders. A better understanding of DLDH’s redox and non-redox features may reveal druggable targets for disease interventions or preventions. Recent advances: In this article, the authors reviews the different roles of DLDH in selected pathological conditions, including DLDH deficiency in humans, DLDH in stroke and neuroprotection, DLDH in skin photo-aging, DLDH and Alzheimer’s disease, DLDH as a non-dehydrogenating protein, and construction of genetically modified DLDH animal models for further studying the role of DLDH in specific pathological conditions. DLDH is also vulnerable to oxidative modifications in pathological conditions. Critical issues: Novel animal models need to be constructed using gene knockdown techniques to investigate the redox- and non-redox roles of DLDH in related metabolic diseases. Specific small molecule DLDH inhibitors need to be discovered. The relationship between modifications of specific amino acid residues in DLDH and a given pathological conditions is an interesting area that remains to be comprehensively evaluated. Future directions: Cell-specific or tissue-specific knockdown of DLDH creating specific pathological conditions will provide more insights into the mechanisms whereby DLDH may have therapeutic values under a variety of pathological conditions." @default.
- W4379383037 created "2023-06-06" @default.
- W4379383037 creator A5057307061 @default.
- W4379383037 creator A5083848125 @default.
- W4379383037 date "2023-06-05" @default.
- W4379383037 modified "2023-09-27" @default.
- W4379383037 title "Roles of dihydrolipoamide dehydrogenase in health and disease" @default.
- W4379383037 cites W1864842455 @default.
- W4379383037 cites W1921797022 @default.
- W4379383037 cites W1922324982 @default.
- W4379383037 cites W1966225852 @default.
- W4379383037 cites W1981845473 @default.
- W4379383037 cites W1989729441 @default.
- W4379383037 cites W1993145355 @default.
- W4379383037 cites W1999366850 @default.
- W4379383037 cites W2005105000 @default.
- W4379383037 cites W2020871447 @default.
- W4379383037 cites W2053022803 @default.
- W4379383037 cites W2054690066 @default.
- W4379383037 cites W2061868451 @default.
- W4379383037 cites W2070263356 @default.
- W4379383037 cites W2095150726 @default.
- W4379383037 cites W2108294918 @default.
- W4379383037 cites W2134958153 @default.
- W4379383037 cites W2146033970 @default.
- W4379383037 cites W2147849026 @default.
- W4379383037 cites W2161567251 @default.
- W4379383037 cites W2203261478 @default.
- W4379383037 cites W2249648250 @default.
- W4379383037 cites W2403371113 @default.
- W4379383037 cites W2762177595 @default.
- W4379383037 cites W2899135780 @default.
- W4379383037 cites W2921594465 @default.
- W4379383037 cites W2981177181 @default.
- W4379383037 cites W4283455030 @default.
- W4379383037 cites W4300457979 @default.
- W4379383037 cites W4362667713 @default.
- W4379383037 doi "https://doi.org/10.1089/ars.2022.0181" @default.
- W4379383037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37276180" @default.
- W4379383037 hasPublicationYear "2023" @default.
- W4379383037 type Work @default.
- W4379383037 citedByCount "0" @default.
- W4379383037 crossrefType "journal-article" @default.
- W4379383037 hasAuthorship W4379383037A5057307061 @default.
- W4379383037 hasAuthorship W4379383037A5083848125 @default.
- W4379383037 hasConcept C120763696 @default.
- W4379383037 hasConcept C181199279 @default.
- W4379383037 hasConcept C185592680 @default.
- W4379383037 hasConcept C2776317432 @default.
- W4379383037 hasConcept C55493867 @default.
- W4379383037 hasConceptScore W4379383037C120763696 @default.
- W4379383037 hasConceptScore W4379383037C181199279 @default.
- W4379383037 hasConceptScore W4379383037C185592680 @default.
- W4379383037 hasConceptScore W4379383037C2776317432 @default.
- W4379383037 hasConceptScore W4379383037C55493867 @default.
- W4379383037 hasLocation W43793830371 @default.
- W4379383037 hasLocation W43793830372 @default.
- W4379383037 hasOpenAccess W4379383037 @default.
- W4379383037 hasPrimaryLocation W43793830371 @default.
- W4379383037 hasRelatedWork W1583528288 @default.
- W4379383037 hasRelatedWork W1628207109 @default.
- W4379383037 hasRelatedWork W1782242319 @default.
- W4379383037 hasRelatedWork W1861512817 @default.
- W4379383037 hasRelatedWork W1906002440 @default.
- W4379383037 hasRelatedWork W1912947570 @default.
- W4379383037 hasRelatedWork W1918426605 @default.
- W4379383037 hasRelatedWork W2027415601 @default.
- W4379383037 hasRelatedWork W2155263227 @default.
- W4379383037 hasRelatedWork W2167598831 @default.
- W4379383037 isParatext "false" @default.
- W4379383037 isRetracted "false" @default.
- W4379383037 workType "article" @default.