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- W4379383902 abstract "The results of the Phase III DESTINY-Breast04 trial of trastuzumab deruxtecan (T-DXd) are leading to a shift in both the classification and treatment of human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer. In this trial, T-DXd was associated with a substantial survival benefit among patients with hormone receptor-positive and hormone receptor-negative disease and low expression of HER2, a biomarker previously considered unactionable in this treatment setting. Herein, we discuss the evolving therapeutic pathway for HER2-low disease, ongoing clinical trials, and the potential challenges and evidence gaps arising with treatment of this patient population." @default.
- W4379383902 created "2023-06-06" @default.
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- W4379383902 date "2023-01-01" @default.
- W4379383902 modified "2023-09-23" @default.
- W4379383902 title "Targeting HER2-low in metastatic breast cancer: an evolving treatment paradigm" @default.
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- W4379383902 doi "https://doi.org/10.1177/17588359231175440" @default.
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