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- W4379389623 abstract "Abstract The evolution of multicellularity paved the way for the origin of complex life on Earth, but little is known about the mechanistic basis of early multicellular evolution. Here, we examine the molecular basis of multicellular adaptation in the Multicellularity Long Term Evolution Experiment (MuLTEE). We demonstrate that cellular elongation, a key adaptation underpinning increased biophysical toughness and organismal size, is convergently driven by downregulation of the chaperone Hsp90. Mechanistically, Hsp90-mediated morphogenesis operates by destabilizing the cyclin-dependent kinase Cdc28, resulting in delayed mitosis and prolonged polarized growth. Reintroduction of Hsp90 expression resulted in shortened cells that formed smaller groups with reduced multicellular fitness. Together, our results show how ancient protein folding systems can be tuned to drive rapid evolution at a new level of biological individuality by revealing novel developmental phenotypes. One sentence summary Downregulation of Hsp90 decouples cell cycle progression and growth to drive the evolution of macroscopic multicellularity." @default.
- W4379389623 created "2023-06-06" @default.
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- W4379389623 date "2023-06-05" @default.
- W4379389623 modified "2023-09-29" @default.
- W4379389623 title "Proteostatic tuning underpins the evolution of novel multicellular traits" @default.
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- W4379389623 doi "https://doi.org/10.1101/2023.05.31.543183" @default.
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