FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379389966> ?p ?o ?g. }

• W4379389966 abstract "Abstract Anesthesia is a major confounding factor in preclinical stroke research as stroke rarely occurs in sedated patients. Moreover, anesthesia affects both brain functions and the stroke outcome acting as neurotoxic or protective agent. So far, no approaches were well suited to induce stroke while imaging hemodynamics along with simultaneous large-scale recording of brain functions in awake animals. For this reason, the first critical hours following the stroke insult and associated functional alteration remain poorly understood. Here, we present a strategy to investigate both stroke hemodynamics and stroke-induced functional alterations without the confounding effect of anesthesia, i.e., under awake condition. Functional ultrasound (fUS) imaging was used to continuously monitor variations in cerebral blood volume (CBV) in +65 brain regions/hemisphere for up to 3hrs after stroke onset. The focal cortical ischemia was induced using a chemo-thrombotic agent suited for permanent middle cerebral artery occlusion in awake rats, and followed by ipsi- and contralesional whiskers stimulation to investigate on the dynamic of the thalamo-cortical functions. Early (0-3hrs) and delayed (day 5) fUS recording enabled to characterize the features of the ischemia (location, CBV loss), spreading depolarizations (occurrence, amplitude) and functional alteration of the somatosensory thalamo-cortical circuits. Post-stroke thalamo-cortical functions were affected not only early after the stroke onset but were also altered secondarly and remotely from the initial insult. Overall, our procedure enables early, continuous, and chronic evaluations of hemodynamics and brain functions which, combined to stroke or other pathologies, aims to better understand physiopathologies toward the development of clinically relevant therapeutic strategies." @default.
• W4379389966 created "2023-06-06" @default.
• W4379389966 creator A5011647847 @default.
• W4379389966 creator A5038095934 @default.
• W4379389966 creator A5085161609 @default.
• W4379389966 date "2023-06-05" @default.
• W4379389966 modified "2023-10-12" @default.
• W4379389966 title "Functional ultrasound imaging of stroke in awake rats" @default.
• W4379389966 cites W1507695852 @default.
• W4379389966 cites W1557649900 @default.
• W4379389966 cites W1632482896 @default.
• W4379389966 cites W1965558130 @default.
• W4379389966 cites W1983246821 @default.
• W4379389966 cites W1988026956 @default.
• W4379389966 cites W1990859989 @default.
• W4379389966 cites W1992294955 @default.
• W4379389966 cites W1996408736 @default.
• W4379389966 cites W2000790789 @default.
• W4379389966 cites W2002836450 @default.
• W4379389966 cites W2006209961 @default.
• W4379389966 cites W2008432587 @default.
• W4379389966 cites W2011670028 @default.
• W4379389966 cites W2024544573 @default.
• W4379389966 cites W2026985912 @default.
• W4379389966 cites W2037886472 @default.
• W4379389966 cites W2053577237 @default.
• W4379389966 cites W2054580619 @default.
• W4379389966 cites W2063430655 @default.
• W4379389966 cites W2065068139 @default.
• W4379389966 cites W2067811903 @default.
• W4379389966 cites W2068892221 @default.
• W4379389966 cites W2072764389 @default.
• W4379389966 cites W2073805301 @default.
• W4379389966 cites W2082641523 @default.
• W4379389966 cites W2088427193 @default.
• W4379389966 cites W2089136110 @default.
• W4379389966 cites W2089838527 @default.
• W4379389966 cites W2095360787 @default.
• W4379389966 cites W2099165579 @default.
• W4379389966 cites W2104351664 @default.
• W4379389966 cites W2118401165 @default.
• W4379389966 cites W2118743338 @default.
• W4379389966 cites W2126481749 @default.
• W4379389966 cites W2135285893 @default.
• W4379389966 cites W2150656345 @default.
• W4379389966 cites W2161097950 @default.
• W4379389966 cites W2162621662 @default.
• W4379389966 cites W2163136512 @default.
• W4379389966 cites W2163492988 @default.
• W4379389966 cites W2174687859 @default.
• W4379389966 cites W2200662479 @default.
• W4379389966 cites W2342952095 @default.
• W4379389966 cites W2462104447 @default.
• W4379389966 cites W2482471309 @default.
• W4379389966 cites W2515535822 @default.
• W4379389966 cites W2568954699 @default.
• W4379389966 cites W2696053297 @default.
• W4379389966 cites W2801072534 @default.
• W4379389966 cites W2811136853 @default.
• W4379389966 cites W2883394240 @default.
• W4379389966 cites W2902168103 @default.
• W4379389966 cites W2964385500 @default.
• W4379389966 cites W2973486294 @default.
• W4379389966 cites W2992571993 @default.
• W4379389966 cites W3015246230 @default.
• W4379389966 cites W3035716958 @default.
• W4379389966 cites W3038945074 @default.
• W4379389966 cites W3039872703 @default.
• W4379389966 cites W3081599307 @default.
• W4379389966 cites W3093424769 @default.
• W4379389966 cites W3107189623 @default.
• W4379389966 cites W3140927539 @default.
• W4379389966 cites W3158782517 @default.
• W4379389966 cites W3165352648 @default.
• W4379389966 cites W3173142891 @default.
• W4379389966 cites W4200427678 @default.
• W4379389966 cites W4206949829 @default.
• W4379389966 cites W4214894385 @default.
• W4379389966 cites W4223585673 @default.
• W4379389966 cites W4236357753 @default.
• W4379389966 cites W4284976721 @default.
• W4379389966 cites W4312057118 @default.
• W4379389966 cites W4385331098 @default.
• W4379389966 doi "https://doi.org/10.1101/2023.05.31.543179" @default.
• W4379389966 hasPublicationYear "2023" @default.
• W4379389966 type Work @default.
• W4379389966 citedByCount "0" @default.
• W4379389966 crossrefType "posted-content" @default.
• W4379389966 hasAuthorship W4379389966A5011647847 @default.
• W4379389966 hasAuthorship W4379389966A5038095934 @default.
• W4379389966 hasAuthorship W4379389966A5085161609 @default.
• W4379389966 hasBestOaLocation W43793899661 @default.
• W4379389966 hasConcept C127413603 @default.
• W4379389966 hasConcept C15744967 @default.
• W4379389966 hasConcept C164705383 @default.
• W4379389966 hasConcept C169760540 @default.
• W4379389966 hasConcept C172497186 @default.
• W4379389966 hasConcept C178853913 @default.
• W4379389966 hasConcept C2780645631 @default.
• W4379389966 hasConcept C42219234 @default.

• next