FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379390623> ?p ?o ?g. }

• W4379390623 abstract "Abstract Profiling compounds and genetic perturbations via high-content imaging has become increasingly popular for drug discovery, but the technique is limited to endpoint images of fixed cells. In contrast, electronic-based devices offer label-free, functional information of live cells, yet current approaches suffer from low-spatial resolution or single-well throughput. Here, we report a semiconductor 96-microplate platform designed for high-resolution real-time impedance “imaging” at scale. Each well features 4,096 electrodes at 25 µm spatial resolution while a miniaturized data interface allows 8× parallel plate operation (768 total wells) within each incubator for enhanced throughputs. New electric field-based, multi-frequency measurement techniques capture >20 parameter images including tissue barrier, cell-surface attachment, cell flatness, and motility every 15 min throughout experiments. Using these real-time readouts, we characterized 16 cell types, ranging from primary epithelial to suspension, and quantified heterogeneity in mixed epithelial and mesenchymal co-cultures. A proof-of-concept screen of 904 diverse compounds using 13 semiconductor microplates demonstrates the platform’s capability for mechanism of action (MOA) profiling with 25 distinct responses identified. The scalability of the semiconductor platform combined with the translatability of the high dimensional live-cell functional parameters expands high-throughput MOA profiling and phenotypic drug discovery applications." @default.
• W4379390623 created "2023-06-06" @default.
• W4379390623 creator A5003286341 @default.
• W4379390623 creator A5004771582 @default.
• W4379390623 creator A5009914258 @default.
• W4379390623 creator A5016192754 @default.
• W4379390623 creator A5020154437 @default.
• W4379390623 creator A5023501820 @default.
• W4379390623 creator A5035117799 @default.
• W4379390623 creator A5035304120 @default.
• W4379390623 creator A5040028357 @default.
• W4379390623 creator A5043484455 @default.
• W4379390623 creator A5049737796 @default.
• W4379390623 creator A5050044905 @default.
• W4379390623 creator A5051453476 @default.
• W4379390623 creator A5057601539 @default.
• W4379390623 creator A5070746696 @default.
• W4379390623 creator A5086778667 @default.
• W4379390623 creator A5088932222 @default.
• W4379390623 creator A5092090311 @default.
• W4379390623 creator A5092090312 @default.
• W4379390623 creator A5092090313 @default.
• W4379390623 date "2023-06-05" @default.
• W4379390623 modified "2023-09-25" @default.
• W4379390623 title "A semiconductor 96-microplate platform for electrical-imaging based high-throughput phenotypic screening" @default.
• W4379390623 cites W1753841117 @default.
• W4379390623 cites W1832906682 @default.
• W4379390623 cites W1912879943 @default.
• W4379390623 cites W1998063139 @default.
• W4379390623 cites W2003405209 @default.
• W4379390623 cites W2041454039 @default.
• W4379390623 cites W2060187083 @default.
• W4379390623 cites W2075562428 @default.
• W4379390623 cites W2076583198 @default.
• W4379390623 cites W2076601321 @default.
• W4379390623 cites W2077492833 @default.
• W4379390623 cites W2092071393 @default.
• W4379390623 cites W2136388349 @default.
• W4379390623 cites W2154555351 @default.
• W4379390623 cites W2179643578 @default.
• W4379390623 cites W2218298963 @default.
• W4379390623 cites W2255395527 @default.
• W4379390623 cites W2509141893 @default.
• W4379390623 cites W2553323458 @default.
• W4379390623 cites W2591885959 @default.
• W4379390623 cites W2616818052 @default.
• W4379390623 cites W2746704802 @default.
• W4379390623 cites W2781527068 @default.
• W4379390623 cites W2788640168 @default.
• W4379390623 cites W2802758935 @default.
• W4379390623 cites W2885684889 @default.
• W4379390623 cites W2889520069 @default.
• W4379390623 cites W2899148412 @default.
• W4379390623 cites W2991525627 @default.
• W4379390623 cites W2998931275 @default.
• W4379390623 cites W3113917069 @default.
• W4379390623 cites W3130336442 @default.
• W4379390623 cites W3132197687 @default.
• W4379390623 cites W3177080426 @default.
• W4379390623 cites W4221004791 @default.
• W4379390623 cites W4225115450 @default.
• W4379390623 cites W4320482525 @default.
• W4379390623 cites W4324303454 @default.
• W4379390623 cites W96287323 @default.
• W4379390623 doi "https://doi.org/10.1101/2023.06.01.543281" @default.
• W4379390623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37333319" @default.
• W4379390623 hasPublicationYear "2023" @default.
• W4379390623 type Work @default.
• W4379390623 citedByCount "0" @default.
• W4379390623 crossrefType "posted-content" @default.
• W4379390623 hasAuthorship W4379390623A5003286341 @default.
• W4379390623 hasAuthorship W4379390623A5004771582 @default.
• W4379390623 hasAuthorship W4379390623A5009914258 @default.
• W4379390623 hasAuthorship W4379390623A5016192754 @default.
• W4379390623 hasAuthorship W4379390623A5020154437 @default.
• W4379390623 hasAuthorship W4379390623A5023501820 @default.
• W4379390623 hasAuthorship W4379390623A5035117799 @default.
• W4379390623 hasAuthorship W4379390623A5035304120 @default.
• W4379390623 hasAuthorship W4379390623A5040028357 @default.
• W4379390623 hasAuthorship W4379390623A5043484455 @default.
• W4379390623 hasAuthorship W4379390623A5049737796 @default.
• W4379390623 hasAuthorship W4379390623A5050044905 @default.
• W4379390623 hasAuthorship W4379390623A5051453476 @default.
• W4379390623 hasAuthorship W4379390623A5057601539 @default.
• W4379390623 hasAuthorship W4379390623A5070746696 @default.
• W4379390623 hasAuthorship W4379390623A5086778667 @default.
• W4379390623 hasAuthorship W4379390623A5088932222 @default.
• W4379390623 hasAuthorship W4379390623A5092090311 @default.
• W4379390623 hasAuthorship W4379390623A5092090312 @default.
• W4379390623 hasAuthorship W4379390623A5092090313 @default.
• W4379390623 hasBestOaLocation W43793906231 @default.
• W4379390623 hasConcept C108225325 @default.
• W4379390623 hasConcept C111919701 @default.
• W4379390623 hasConcept C127313418 @default.
• W4379390623 hasConcept C1491633281 @default.
• W4379390623 hasConcept C15526883 @default.
• W4379390623 hasConcept C157764524 @default.
• W4379390623 hasConcept C171250308 @default.
• W4379390623 hasConcept C185592680 @default.
• W4379390623 hasConcept C187191949 @default.

• next