Matches in SemOpenAlex for { <https://semopenalex.org/work/W4379467360> ?p ?o ?g. }
- W4379467360 abstract "Nogo-66 receptor 1 (NgR1) binds a variety of structurally dissimilar ligands in the adult central nervous system to inhibit axon extension. Disruption of ligand binding to NgR1 and subsequent signaling can improve neuron outgrowth, making NgR1 an important therapeutic target for diverse neurological conditions such as spinal crush injuries and Alzheimer's disease. Human NgR1 serves as a receptor for mammalian orthoreovirus (reovirus), but the mechanism of virus-receptor engagement is unknown. To elucidate how NgR1 mediates cell binding and entry of reovirus, we defined the affinity of interaction between virus and receptor, determined the structure of the virus-receptor complex, and identified residues in the receptor required for virus binding and infection. These studies revealed that central NgR1 surfaces form a bridge between two copies of viral capsid protein σ3, establishing that σ3 serves as a receptor ligand for reovirus. This unusual binding interface produces high-avidity interactions between virus and receptor to prime early entry steps. These studies refine models of reovirus cell-attachment and highlight the evolution of viruses to engage multiple receptors using distinct capsid components." @default.
- W4379467360 created "2023-06-07" @default.
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- W4379467360 date "2023-06-05" @default.
- W4379467360 modified "2023-09-28" @default.
- W4379467360 title "NgR1 binding to reovirus reveals an unusual bivalent interaction and a new viral attachment protein" @default.
- W4379467360 cites W1491610362 @default.
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- W4379467360 cites W1559609143 @default.
- W4379467360 cites W1592046893 @default.
- W4379467360 cites W1607125092 @default.
- W4379467360 cites W1939985926 @default.
- W4379467360 cites W1954119403 @default.
- W4379467360 cites W1963681795 @default.
- W4379467360 cites W1970863640 @default.
- W4379467360 cites W1972636859 @default.
- W4379467360 cites W1974262428 @default.
- W4379467360 cites W1978778887 @default.
- W4379467360 cites W1982097445 @default.
- W4379467360 cites W1983716826 @default.
- W4379467360 cites W1984355682 @default.
- W4379467360 cites W1991024347 @default.
- W4379467360 cites W1991539783 @default.
- W4379467360 cites W1993433521 @default.
- W4379467360 cites W1997019840 @default.
- W4379467360 cites W1997194905 @default.
- W4379467360 cites W2001747259 @default.
- W4379467360 cites W2004678742 @default.
- W4379467360 cites W2004734349 @default.
- W4379467360 cites W2006112136 @default.
- W4379467360 cites W2006519197 @default.
- W4379467360 cites W2008217463 @default.
- W4379467360 cites W2009929706 @default.
- W4379467360 cites W2011760921 @default.
- W4379467360 cites W2013028378 @default.
- W4379467360 cites W2019877102 @default.
- W4379467360 cites W2034844685 @default.
- W4379467360 cites W2035132495 @default.
- W4379467360 cites W2035489194 @default.
- W4379467360 cites W2036136241 @default.
- W4379467360 cites W2044963582 @default.
- W4379467360 cites W2047946045 @default.
- W4379467360 cites W2050057735 @default.
- W4379467360 cites W2051195928 @default.
- W4379467360 cites W2052192720 @default.
- W4379467360 cites W2056511071 @default.
- W4379467360 cites W2057363904 @default.
- W4379467360 cites W2060328567 @default.
- W4379467360 cites W2060783710 @default.
- W4379467360 cites W2061727508 @default.
- W4379467360 cites W2063723998 @default.
- W4379467360 cites W2063924821 @default.
- W4379467360 cites W2064914206 @default.
- W4379467360 cites W2069087293 @default.
- W4379467360 cites W2070118546 @default.
- W4379467360 cites W2073322731 @default.
- W4379467360 cites W2078484077 @default.
- W4379467360 cites W2081528639 @default.
- W4379467360 cites W2082571523 @default.
- W4379467360 cites W2082824466 @default.
- W4379467360 cites W2085706956 @default.
- W4379467360 cites W2087036692 @default.
- W4379467360 cites W2093085365 @default.
- W4379467360 cites W2095549733 @default.
- W4379467360 cites W2097625363 @default.
- W4379467360 cites W2098781795 @default.
- W4379467360 cites W2099625816 @default.
- W4379467360 cites W2103483100 @default.
- W4379467360 cites W2108448231 @default.
- W4379467360 cites W2110596532 @default.
- W4379467360 cites W2112211527 @default.
- W4379467360 cites W2121729624 @default.
- W4379467360 cites W2122170158 @default.
- W4379467360 cites W2127086515 @default.
- W4379467360 cites W2129588435 @default.
- W4379467360 cites W2133064444 @default.
- W4379467360 cites W2138127366 @default.
- W4379467360 cites W2149942972 @default.
- W4379467360 cites W2157477381 @default.